The role of Melipramine in the treatment of bladder instability.

Observations with Melipramine (imipramine) coated tablet used in the treatment of bladder instability are reported. The patients were selected on the basis of urodynamic examinations. Five men and 45 women were treated for 2 and 4 weeks. The patients recorded the number of urinations and urgency as well as the quantity of voided urine. The effectivity of treatment was controlled by urodynamic examinations. Melipramine (3 x 2 coated tablet) given in 60-mg daily doses, favourably influenced the symptoms. The effectivity of treatment reached 90% in the selected patients. Side-effects developed in 5 cases: in 3 patients the treatment had to be discontinued because of palpitation, feeling weakness. According to the authors' opinion Melipramine is a useful therapeutic means in the treatment of bladder instability.