蛋白质翻译后的化学修饰——III。翻译后化学修饰氨基酸及其衍生物的鉴定和定量分析方法的最新进展。

K K Han, A Martinage
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引用次数: 19

摘要

1. 氨基酸及其衍生物的化学修饰主要是由于不同的翻译后酶促反应。2. 列举了产生氨基酸的酶促反应,如乙酰化-、甲酰化-、甲基化-磷酸化-、磺化-、羟基化、ADP核糖基化-、羧化-、酰胺化-、腺苷化-、糖基化-、泛素化-、烯酰化和酰化,并对分析方法进行了报道和广泛综述。3.成熟后翻译后修饰的交联分子,如桥莫因、异位桥莫因、羟基-、赖基吡啶啉、3-羟基吡啶衍生物、成熟弹性蛋白和胶原蛋白中最近发现的环戊烯甘氨酸、海胆胚胎受精包膜中发现的新型酪氨酸衍生物pulcherosine、弹性蛋白中的二酪氨酸。列举了γ -谷氨酰基赖氨酸异肽交联分子等,并对理化方法和分析方法进行了广泛的综述和讨论。4. 我们也报道了在分析过程中遇到的翻译后修饰的其他后果,如n端糖基化位点、磷酸化位点和/或硫酸化位点的逐步Edman降解。
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Post-translational chemical modifications of proteins--III. Current developments in analytical procedures of identification and quantitation of post-translational chemically modified amino acid(s) and its derivatives.

1. The Chemical modifications of amino acids and their derivatives are mainly due to different post-translational enzymatic reactions. 2. The enzymatic reactions resulting in amino acids such as acetylation-, formylation, methylation-phosphorylation-, sulfation-, hydroxylation, ADP ribosylation-, carboxylation-, amidation-, adenylylation-, glycosylation-, ubiquitination-, prenylation and acylation are listed and analytical methods are reported and extensively reviewed. 3. The post-translationally modified cross-linking molecules after maturations such as desmosines, allo-desmosine, hydroxy-, lysylpyridinoline, 3-hydroxypyridinium derivatives, cyclopentenosine recently found in matured elastin, and in collagen, and pulcherosine a novel tyrosine-derived found in fertilization envelope of Sea Urchin embryo, di-tyrosine in resilin, gamma-glutamyl-lysine isopeptide cross-linking molecule etc. are listed and both physico-chemical and analytical methods are extensively reviewed and discussed. 4. Other consequences of post-translational modifications encountered in the analytical procedure such as N-terminal step-wise Edman degradation of glycosylated site(s), phosphorylated-site(s) and or sulfated-site(s) were also reported by us.

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