[化学品的免疫毒性]。

J Sawada
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引用次数: 0

摘要

免疫毒性是指异种生物对宿主免疫功能的有害影响,其结果是对传染性病原体和肿瘤的易感性增强。据报道,各种环境化学物质,如药品、食品添加剂、食品和饮用水中的污染化学物质、杀虫剂和空气中的化学物质,对实验动物和人类产生免疫毒性作用。本文介绍了免疫反应的机制、典型免疫毒性化学物质对免疫系统的影响以及检测免疫毒性的方法。此外,对免疫毒性评价的策略和指南进行了简要概述和讨论。
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[Immunotoxicity of chemicals].

Immunotoxicity is the detrimental effects of xenobiotics on immune functions of hosts, which result in enhanced susceptibility to infectious agents and tumours. A variety of environmental chemicals, such as pharmaceuticals, food additives, contaminating chemicals in food and drinking water, pesticides, and airborne chemicals, have been reported to exert immunotoxic effects on experimental animals and humans. In this paper, the mechanisms of immune responses, the effects of typical immunotoxic chemicals on the immune systems, and the methods for detecting immunotoxicity were described. In addition, the strategies and guidelines for immunotoxicity assessment were briefly outlined and discussed.

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