甜菊糖苷对大鼠致畸性的研究。

M Usami, K Sakemi, K Kawashima, M Tsuda, Y Ohno
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引用次数: 0

摘要

研究了甜菊糖甙的致畸性。从妊娠第6 ~ 15天,以0、250、500、1000 mg/kg/天的剂量,将甜菊糖甙溶解于蒸馏水中,每天灌胃1次。妊娠第20天处死妊娠大鼠,检查胎儿畸形情况。甜菊糖甙未引起妊娠大鼠和胎儿畸形发生率增加,也未出现中毒症状。结果表明,甜菊糖甙灌胃对大鼠无致畸作用。据估计,妊娠大鼠和胎鼠的不良反应水平均超过1000 mg/kg/天。
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[Teratogenicity study of stevioside in rats].

Teratogenicity of stevioside was examined in rats. Stevioside dissolved in distilled water was given to pregnant Wistar rats by gavage once a day from day 6 through 15 of pregnancy at doses of 0, 250, 500 and 1000 mg/kg/day. The pregnant rats were sacrificed on day 20 of pregnancy and their fetuses were examined for malformation. Stevioside caused no increased incidences of fetal malformation, and no toxic signs in the pregnant rats and the fetuses. It was concluded that stevioside has no teratogenicity in rats when given by gavage. The no observable adverse effect level was estimated to be over 1000 mg/kg/day for both pregnant rats and rat fetuses.

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