[Wistar大鼠硫辛硫磷28天重复给药毒性试验]。

S Suzuki, Y Ogawa, E Kamata, K Naito, T Umemura, M Saito, T Kaneko, Y Kurokawa
{"title":"[Wistar大鼠硫辛硫磷28天重复给药毒性试验]。","authors":"S Suzuki,&nbsp;Y Ogawa,&nbsp;E Kamata,&nbsp;K Naito,&nbsp;T Umemura,&nbsp;M Saito,&nbsp;T Kaneko,&nbsp;Y Kurokawa","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A 28-day oral toxicity test of Phoxim was carried out in male and female Slc: Wistar rats given dose levels of 0, 7.5, 75 and 750 mg/kg/day by gavage. A 14-day recovery test was conducted for animals receiving the 750 mg/kg dose level. There were no deaths with any dose and food consumption and growth were not affected. No specific changes were observed in any of the hematological parameters investigated. At the 750 mg/kg level, significant increases of liver, kidney, and adrenal gland weights were observed in both sexes, which persisted throughout the recovery period. Hepatic lesions with necrosis and swelling of hepatocytes were also observed with the highest dose, but these changes appeared to be reversible because they were no longer present after the recovery period. At doses of 7.5 mg/kg and above, remarkable inhibition of the serum cholinesterase activity was observed in both sexes. This persisting in female rats after the recovery period. Based on these results, the no-observed-effect level (NOEL) was concluded to be less than 7.5 mg/kg/day under the present experimental conditions.</p>","PeriodicalId":11656,"journal":{"name":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","volume":" 112","pages":"40-7"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[A 28-day repeated dose toxicity test of Phoxim in Wistar rats].\",\"authors\":\"S Suzuki,&nbsp;Y Ogawa,&nbsp;E Kamata,&nbsp;K Naito,&nbsp;T Umemura,&nbsp;M Saito,&nbsp;T Kaneko,&nbsp;Y Kurokawa\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 28-day oral toxicity test of Phoxim was carried out in male and female Slc: Wistar rats given dose levels of 0, 7.5, 75 and 750 mg/kg/day by gavage. A 14-day recovery test was conducted for animals receiving the 750 mg/kg dose level. There were no deaths with any dose and food consumption and growth were not affected. No specific changes were observed in any of the hematological parameters investigated. At the 750 mg/kg level, significant increases of liver, kidney, and adrenal gland weights were observed in both sexes, which persisted throughout the recovery period. Hepatic lesions with necrosis and swelling of hepatocytes were also observed with the highest dose, but these changes appeared to be reversible because they were no longer present after the recovery period. At doses of 7.5 mg/kg and above, remarkable inhibition of the serum cholinesterase activity was observed in both sexes. This persisting in female rats after the recovery period. Based on these results, the no-observed-effect level (NOEL) was concluded to be less than 7.5 mg/kg/day under the present experimental conditions.</p>\",\"PeriodicalId\":11656,\"journal\":{\"name\":\"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences\",\"volume\":\" 112\",\"pages\":\"40-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

以0、7.5、75、750mg /kg/d灌胃给药,对雄性和雌性Slc: Wistar大鼠进行了28天的口服毒性试验。接受750 mg/kg剂量水平的动物进行了14天的恢复试验。没有任何剂量的死亡,食物消耗和生长也没有受到影响。没有观察到任何血液学参数的特殊变化。在750 mg/kg水平下,两性肝脏、肾脏和肾上腺重量显著增加,并持续整个恢复期。在最高剂量下也观察到肝细胞坏死和肿胀的肝脏病变,但这些变化似乎是可逆的,因为它们在恢复期后不再存在。在7.5 mg/kg及以上的剂量下,两性血清胆碱酯酶活性均被显著抑制。这种情况在恢复期后的雌性大鼠中持续存在。根据上述结果,在本实验条件下,无观察效应水平(NOEL)小于7.5 mg/kg/day。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[A 28-day repeated dose toxicity test of Phoxim in Wistar rats].

A 28-day oral toxicity test of Phoxim was carried out in male and female Slc: Wistar rats given dose levels of 0, 7.5, 75 and 750 mg/kg/day by gavage. A 14-day recovery test was conducted for animals receiving the 750 mg/kg dose level. There were no deaths with any dose and food consumption and growth were not affected. No specific changes were observed in any of the hematological parameters investigated. At the 750 mg/kg level, significant increases of liver, kidney, and adrenal gland weights were observed in both sexes, which persisted throughout the recovery period. Hepatic lesions with necrosis and swelling of hepatocytes were also observed with the highest dose, but these changes appeared to be reversible because they were no longer present after the recovery period. At doses of 7.5 mg/kg and above, remarkable inhibition of the serum cholinesterase activity was observed in both sexes. This persisting in female rats after the recovery period. Based on these results, the no-observed-effect level (NOEL) was concluded to be less than 7.5 mg/kg/day under the present experimental conditions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
[Cyanocobalamin Reference Standard (Control 951) of the National Institute of Health Sciences]. [dl-Camphor Reference Standard (Control 951) of the National Institute of Health Sciences]. [Lysozyme Reference Standard (Control 951) of the National Institute of Health Sciences]. [The Somatropin Reference Standard (Control 951) of the National Institute of Health Sciences]. [Studies on "Fast Green FCF Standard" for the dye standard on the National Institute of Health Sciences].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1