科克市学龄儿童麻疹免疫调查。

C Foley-Nolan, C Conlon, E Keane, M O'Sullivan, F Ryan
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摘要

迄今为止,爱尔兰共和国的麻疹监测一直依赖于临床诊断感染的通报和监测覆盖面的人工系统。鉴于1995年在联合王国预计会出现麻疹流行病,认为审查麻疹流行病学和获得爱尔兰共和国科克市麻疹免疫的基线血清流行病学数据是及时的。测定了2000名5 ~ 15岁学龄儿童唾液中麻疹IgG的年龄特异性流行率。该研究还比较了有和没有麻疹疫苗接种史或感染史的儿童的易感性。发现父母提供的病史在告知疫苗接种实践方面是不可靠的,因为102名血清阴性儿童中有79名被归类为免疫儿童。5至10岁儿童对麻疹免疫的比例为91.9%,11至15岁儿童为95.8%。研究结果对未来预防和控制策略的意义进行了讨论。
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Survey of immunity to measles in schoolchildren in Cork.

Surveillance of measles in the Republic of Ireland has relied until now on notifications of clinically diagnosed infections and a manual system for monitoring coverage. In the light of a measles epidemic predicted in the United Kingdom in 1995, it was considered timely to review the epidemiology of measles and obtain baseline seroepidemiological data on measles immunity in Cork City in the Republic of Ireland. The age specific prevalence of measles IgG in saliva from 2000 schoolchildren aged 5 to 15 years was determined. The study also compared susceptibility rates in children with and without a history of measles vaccination or infection. Histories provided by parents were found to be unreliable in informing vaccination practice, as 79 of the 102 seronegative children would have been classified as immune. The proportion of children immune to measles, as gauged by seropositivity, was 91.9% in children aged 5 to 10 years and 95.8% in 11 to 15 year olds. The implications of the study results are discussed in relation to future prevention and control strategies.

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