甲状腺素对大鼠肝、肺肿瘤发展的调节作用

K Takegawa, K Mitsumori, H Onodera, T Shimo, M Takahashi, K Yasuhara, M Takahashi
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引用次数: 0

摘要

为了探讨甲状腺素和肝酶诱导剂是否改变肝脏或肺部的肿瘤发生,6周龄雄性F344大鼠单次皮下注射DHPN, 1周后开始给予含有甲状腺素的水,即磺胺二甲氧嘧啶(SDM)、丙硫脲嘧啶(PTU)和硫氰酸钾(KSCN),或酶诱导剂苯巴比妥(PB),连续19周,不受限制。虽然与对照组相比,PB组肝脏中GST-P阳性灶的数量显著增加,但SDM、PTU和PB组没有明显波动。在肺方面,SDM、KSCN和PB可能会促进肺肿瘤的发生,因为用这些化合物治疗的组肺泡上皮增生的多样性增加。
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[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].

In order to investigate whether goitrogens and liver enzyme-inducers modify the tumorigenesis in the liver or lung, 6-week old male F344 rats were given single subcutaneous injection of DHPN, and starting one week later received water containing goitrogens, namely sulfadimethoxine (SDM), propylthiouracil (PTU) and potassium thiocyanate (KSCN), or an enzyme-inducer, phenobarbital (PB), for 19 weeks ad libitum. Although the number of GST-P positive foci in the liver was significantly increased in the PB group as compared to the control group, there were no significant fluctuations in the SDM, PTU and PB groups. With respect to the lung, it is suggested that SDM, KSCN and PB may enhance the lung tumorigenesis, since the multiplicities of hyperplasias of alveolar epithelia were increased in groups treated with these compounds.

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