生长因子:肾衰竭的未来前景。

Mineral and electrolyte metabolism Pub Date : 1998-01-01 DOI:10.1159/000057347

D Fouque

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引用次数: 6

摘要

慢性肾功能衰竭与生长激素/胰岛素样生长因子-1轴异常有关。此外，营养状况对这条轴有很强的调节作用。由于这些激素参与儿童的生长和成人正常身体组成的维持，实验和临床研究已经测试了这些重组生长因子的代谢作用。这些生长因子已被用于各种情况，如急性肾功能衰竭的恢复，慢性肾功能衰竭的蛋白质代谢，尿毒症儿童的生长改善，非透析尿毒症患者肾功能的增加，以及成人维持透析患者营养不良的潜在治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Growth factors: future prospects in renal failure.

Chronic renal failure is associated with an abnormal growth hormone/insulin-like growth factor-1 axis. In addition, nutritional status strongly regulates this axis. Because these hormones are involved in growth in children and maintenance of a normal body composition in adults, experimental and clinical studies have tested the metabolic effects of these recombinant growth factors. Various conditions in which these growth factors have been administered have been reported, such as the recovery of acute renal failure, protein metabolism in chronic renal failure, growth improvement in uremic children, the increase in renal function in nondialyzed uremic patients, and the potential treatment of malnutrition in adult maintenance dialysis patients.

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