{"title":"甲基磺酰基咪唑基硝苯地平类似物的合成及钙通道拮抗剂活性","authors":"A Shafiee , A.R Dehpour , F Hadizadeh , M Azimi","doi":"10.1016/S0031-6865(98)00004-1","DOIUrl":null,"url":null,"abstract":"<div><p><span>Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound </span><strong>6n</strong> was found to be the most active.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 2","pages":"Pages 75-79"},"PeriodicalIF":0.0000,"publicationDate":"1998-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00004-1","citationCount":"27","resultStr":"{\"title\":\"Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent\",\"authors\":\"A Shafiee , A.R Dehpour , F Hadizadeh , M Azimi\",\"doi\":\"10.1016/S0031-6865(98)00004-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound </span><strong>6n</strong> was found to be the most active.</p></div>\",\"PeriodicalId\":19830,\"journal\":{\"name\":\"Pharmaceutica acta Helvetiae\",\"volume\":\"73 2\",\"pages\":\"Pages 75-79\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00004-1\",\"citationCount\":\"27\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutica acta Helvetiae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031686598000041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound 6n was found to be the most active.
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