M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino
{"title":"系统性红斑狼疮患者血清和尿硝酸盐水平的前瞻性研究。","authors":"M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino","doi":"10.1093/rheumatology/37.9.972","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study prospectively whether serum and urinary nitrate levels are related to lupus activity.</p><p><strong>Methods: </strong>Fifty patients with systemic lupus erythematosus (SLE) were studied prospectively for 2 yr. Every 4 months, the SLE Disease Activity Index (SLEDAI) was administered to the patients, and blood and 24 h urine samples were obtained; 88 healthy controls were also studied. Nitrate levels were measured by the Greiss method. Statistical analyses were performed using standard parametric and non-parametric tests, and analysis of serial measurements.</p><p><strong>Results: </strong>Twelve patients suffered infections, 12 active nephritis and 17 episodes of non-renal activity. By analysis of serial measurements, serum and urinary nitrate levels did not correlate with SLEDAI. C-Reactive protein (CRP) levels, presence of infection and creatinine clearance weakly influenced nitrate levels.</p><p><strong>Conclusions: </strong>In SLE, serum and urinary nitrate levels do not parallel lupus activity. Other variables, related or not to SLE, seem to affect these levels.</p>","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"972-7"},"PeriodicalIF":0.0000,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.972","citationCount":"19","resultStr":"{\"title\":\"Prospective study of serum and urinary nitrate levels in patients with systemic lupus erythematosus.\",\"authors\":\"M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino\",\"doi\":\"10.1093/rheumatology/37.9.972\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study prospectively whether serum and urinary nitrate levels are related to lupus activity.</p><p><strong>Methods: </strong>Fifty patients with systemic lupus erythematosus (SLE) were studied prospectively for 2 yr. Every 4 months, the SLE Disease Activity Index (SLEDAI) was administered to the patients, and blood and 24 h urine samples were obtained; 88 healthy controls were also studied. Nitrate levels were measured by the Greiss method. Statistical analyses were performed using standard parametric and non-parametric tests, and analysis of serial measurements.</p><p><strong>Results: </strong>Twelve patients suffered infections, 12 active nephritis and 17 episodes of non-renal activity. By analysis of serial measurements, serum and urinary nitrate levels did not correlate with SLEDAI. C-Reactive protein (CRP) levels, presence of infection and creatinine clearance weakly influenced nitrate levels.</p><p><strong>Conclusions: </strong>In SLE, serum and urinary nitrate levels do not parallel lupus activity. Other variables, related or not to SLE, seem to affect these levels.</p>\",\"PeriodicalId\":9307,\"journal\":{\"name\":\"British journal of rheumatology\",\"volume\":\"37 9\",\"pages\":\"972-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.972\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British journal of rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/rheumatology/37.9.972\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/rheumatology/37.9.972","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prospective study of serum and urinary nitrate levels in patients with systemic lupus erythematosus.
Objective: To study prospectively whether serum and urinary nitrate levels are related to lupus activity.
Methods: Fifty patients with systemic lupus erythematosus (SLE) were studied prospectively for 2 yr. Every 4 months, the SLE Disease Activity Index (SLEDAI) was administered to the patients, and blood and 24 h urine samples were obtained; 88 healthy controls were also studied. Nitrate levels were measured by the Greiss method. Statistical analyses were performed using standard parametric and non-parametric tests, and analysis of serial measurements.
Results: Twelve patients suffered infections, 12 active nephritis and 17 episodes of non-renal activity. By analysis of serial measurements, serum and urinary nitrate levels did not correlate with SLEDAI. C-Reactive protein (CRP) levels, presence of infection and creatinine clearance weakly influenced nitrate levels.
Conclusions: In SLE, serum and urinary nitrate levels do not parallel lupus activity. Other variables, related or not to SLE, seem to affect these levels.
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