{"title":"丙戊酸对奥卡西平在大鼠体内药动学的影响","authors":"K.M Matar , P.J Nicholls , S.A Bawazir , M.I Al-Hassan , A Tekle","doi":"10.1016/S0031-6865(98)00030-2","DOIUrl":null,"url":null,"abstract":"<div><p><span>The pharmacokinetics<span> of oxcarbazepine (30 mg kg</span></span><sup>−1</sup><span>, po), administered for 1 week, was studied in rats pre-treated for 2 weeks with valproic acid (100 mg kg</span><sup>−1</sup><span>, po). Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. No significant changes were observed in the mean values of OXC pharmacokinetic parameters (</span><em>C</em><sub>max</sub>, <em>T</em><sub>max</sub>, <em>t</em><sub>1/2</sub> and AUC<sub>o–oo</sub>) between the control and the pre-treated groups. The findings of this study suggest that OXC metabolism in the rat is apparently not affected by valproic acid, and the lack of effect may be attributed to the different pathways of biotransformation of the two drugs.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 5","pages":"Pages 247-250"},"PeriodicalIF":0.0000,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00030-2","citationCount":"6","resultStr":"{\"title\":\"Effect of valproic acid on the pharmacokinetic profile of oxcarbazepine in the rat\",\"authors\":\"K.M Matar , P.J Nicholls , S.A Bawazir , M.I Al-Hassan , A Tekle\",\"doi\":\"10.1016/S0031-6865(98)00030-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The pharmacokinetics<span> of oxcarbazepine (30 mg kg</span></span><sup>−1</sup><span>, po), administered for 1 week, was studied in rats pre-treated for 2 weeks with valproic acid (100 mg kg</span><sup>−1</sup><span>, po). Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. No significant changes were observed in the mean values of OXC pharmacokinetic parameters (</span><em>C</em><sub>max</sub>, <em>T</em><sub>max</sub>, <em>t</em><sub>1/2</sub> and AUC<sub>o–oo</sub>) between the control and the pre-treated groups. The findings of this study suggest that OXC metabolism in the rat is apparently not affected by valproic acid, and the lack of effect may be attributed to the different pathways of biotransformation of the two drugs.</p></div>\",\"PeriodicalId\":19830,\"journal\":{\"name\":\"Pharmaceutica acta Helvetiae\",\"volume\":\"73 5\",\"pages\":\"Pages 247-250\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00030-2\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutica acta Helvetiae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031686598000302\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000302","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
摘要
用丙戊酸(100 mg kg - 1, po)预处理2周的大鼠，研究给药1周的奥卡西平(30 mg kg - 1, po)的药代动力学。用高效液相色谱法测定给药后24小时内奥卡西平(OXC)的血浆水平。对照组与预处理组OXC药代动力学参数(Cmax、Tmax、t1/2和AUCo-oo)的平均值均无显著变化。本研究结果提示丙戊酸对大鼠体内OXC代谢明显没有影响，可能与两种药物的生物转化途径不同有关。
Effect of valproic acid on the pharmacokinetic profile of oxcarbazepine in the rat
The pharmacokinetics of oxcarbazepine (30 mg kg−1, po), administered for 1 week, was studied in rats pre-treated for 2 weeks with valproic acid (100 mg kg−1, po). Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. No significant changes were observed in the mean values of OXC pharmacokinetic parameters (Cmax, Tmax, t1/2 and AUCo–oo) between the control and the pre-treated groups. The findings of this study suggest that OXC metabolism in the rat is apparently not affected by valproic acid, and the lack of effect may be attributed to the different pathways of biotransformation of the two drugs.
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