新修饰核苷的合成与测试。

Nucleosides & nucleotides Pub Date : 1999-04-01 DOI:10.1080/15257779908041490

M E Jung, C J Nichols, O Kretschik, Y Xu

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引用次数: 11

摘要

近年来，研究人员开发了几种高效合成改性核苷的新途径。我们制备了亚甲基扩展的氧乙酸异核苷1a-c和L-2′，3′-二脱氧异核苷2abc (oxa和thia类似物)的D-和L-2′，3′-二脱氧异核苷2abc，以及制备l -核糖和2-脱氧l -核糖3ab及其修饰核苷4的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis and testing of new modified nucleosides.

New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.

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Nucleosides & nucleotides

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