S C Cavalcanti, Y Xiang, M G Newton, R F Schinazi, Y C Cheng, C K Chu
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引用次数: 5
摘要
合成了一系列2'，3'-二脱氧-2'-氟- l -三戊呋喃基核苷，作为潜在的抗病毒药物。合成的化合物对HIV-1、HBV、HSV-1和HSV-2进行了抗感染评价。在合成的类似物中，只有胞嘧啶衍生物对HIV和HBV具有中等的抗病毒活性。
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.
A series of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV.
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