维生素D、钙和磷酸盐对PTH基因表达的转录和转录后调控。

Mineral and electrolyte metabolism Pub Date : 1999-07-01 DOI:10.1159/000057471

A Sela-Brown, T Naveh-Many, J Silver

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引用次数: 13

摘要

1,25(OH)(2)D(3)维生素D的生物活性代谢物在肾近端小管中由肝脏代谢物25(OH) D合成。缺乏1,25(OH)(2)D(3)与继发性甲状旁腺功能亢进的发病机制有关，而1,25(OH)(2)D(3)本身可有效用于治疗肾功能衰竭患者，预防继发性甲状旁腺功能亢进。这种疗法的科学基础是发现1,25(OH)(2)D(3)在体内和体外都能有效地降低PTH基因的转录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcriptional and post-transcriptional regulation of PTH gene expression by vitamin D, calcium and phosphate.

1,25(OH)(2)D(3) the biologically active metabolite of vitamin D is synthesized in the renal proximal tubules from the hepatic metabolite 25 (OH)D. Lack of 1,25(OH)(2)D(3) is relevant to the pathogenesis of secondary hyperparathyroidism, and 1,25(OH)(2)D(3) itself is used effectively in the management of renal failure patients to prevent secondary hyperparathyroidism. The scientific basis of this therapy is the finding that 1,25(OH)(2)D(3) potently decreases PTH gene transcription both in vitro and in vivo.

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