人类去西帕胺敏感的去甲肾上腺素转运体及其功能中特定氨基酸的重要性

H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss
{"title":"人类去西帕胺敏感的去甲肾上腺素转运体及其功能中特定氨基酸的重要性","authors":"H. Bönisch,&nbsp;F. Runkel,&nbsp;C Roubert,&nbsp;B. Giros,&nbsp;M. Brüss","doi":"10.1111/j.1365-2680.1999.tb00005.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p><b>1</b> This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na<sup>+</sup>/CI<sup>-</sup> -dependent noradrenaline transporter (hNAT) and its gene.</p>\n <p><b>2</b> Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.</p>\n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":"19 6","pages":"327-333"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00005.x","citationCount":"18","resultStr":"{\"title\":\"The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function\",\"authors\":\"H. Bönisch,&nbsp;F. Runkel,&nbsp;C Roubert,&nbsp;B. Giros,&nbsp;M. Brüss\",\"doi\":\"10.1111/j.1365-2680.1999.tb00005.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p><b>1</b> This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na<sup>+</sup>/CI<sup>-</sup> -dependent noradrenaline transporter (hNAT) and its gene.</p>\\n <p><b>2</b> Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.</p>\\n </div>\",\"PeriodicalId\":100151,\"journal\":{\"name\":\"Autonomic and Autacoid Pharmacology\",\"volume\":\"19 6\",\"pages\":\"327-333\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00005.x\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autonomic and Autacoid Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00005.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00005.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18

摘要

本文综述了人Na+/CI-依赖性去甲肾上腺素转运蛋白(hNAT)及其基因的生理、药理学和分子生物学研究进展。此外,作者还描述了hNAT的自然变异,并介绍了通过hNAT的定点诱变获得的新结果,这些结果增加了我们对与hNAT结合的底物、共底物和抑制剂密切相关的结构域和氨基酸的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function

1 This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/CI- -dependent noradrenaline transporter (hNAT) and its gene.

2 Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1