人类去西帕胺敏感的去甲肾上腺素转运体及其功能中特定氨基酸的重要性

H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss
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引用次数: 18

摘要

本文综述了人Na+/CI-依赖性去甲肾上腺素转运蛋白(hNAT)及其基因的生理、药理学和分子生物学研究进展。此外,作者还描述了hNAT的自然变异,并介绍了通过hNAT的定点诱变获得的新结果,这些结果增加了我们对与hNAT结合的底物、共底物和抑制剂密切相关的结构域和氨基酸的理解。
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The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function

1 This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/CI- -dependent noradrenaline transporter (hNAT) and its gene.

2 Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.

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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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