真核细胞的胞内脂质颗粒

Dagmar Zweytick, Karin Athenstaedt, Günther Daum
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引用次数: 321

摘要

在这篇综述文章中,我们描述了三种不同的真核物种,即哺乳动物细胞,植物和酵母细胞内脂质颗粒的特性。所有类型细胞的脂质颗粒都有一个共同的结构。中性脂的疏水性核心被含有少量蛋白质的磷脂膜单层所包围。哺乳动物细胞和植物的脂质颗粒含有特定种类的多肽,主要是脂磷脂和油蛋白,而酵母脂质颗粒含有一组更复杂的酶,这些酶参与脂质生物合成。讨论了脂质颗粒作为储存室和代谢细胞器的功能及其与其他亚细胞组分的相互作用。此外,提出了脂质颗粒的生物发生模型,并在不同物种之间进行了比较。
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Intracellular lipid particles of eukaryotic cells

In this review article we describe characterization of intracellular lipid particles of three different eukaryotic species, namely mammalian cells, plants and yeast. Lipid particles of all types of cells share a general structure. A hydrophobic core of neutral lipids is surrounded by a membrane monolayer of phospholipids which contains a minor amount of proteins. Whereas lipid particles from mammalian cells and plants harbor specific classes of polypeptides, mainly perilipins and oleosins, respectively, yeast lipid particles contain a more complex set of enzymes which are involved in lipid biosynthesis. Function of lipid particles as storage compartment and metabolic organelle, and their interaction with other subcellular fractions are discussed. Furthermore, models for the biogenesis of lipid particles are presented and compared among the different species.

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