A Baykal, A B Iskit, E Hamaloglu, M O Guc, G Hascelik, I Sayek
{"title":"褪黑素在脂多糖攻击后调节肠系膜血流和TNFalpha浓度。","authors":"A Baykal, A B Iskit, E Hamaloglu, M O Guc, G Hascelik, I Sayek","doi":"10.1080/110241500750008484","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of various doses of melatonin on reduction in mesenteric blood flow (MBF) and increase in tumour necrosis factor alpha (TNFalpha) concentration caused by injection of lipopolysaccharide (LPS).</p><p><strong>Design: </strong>University Hospital, Turkey.</p><p><strong>Setting: </strong>Open experimental study.</p><p><strong>Animals: </strong>59 Swiss albino mice.</p><p><strong>Interventions: </strong>Animals were injected with melatonin solvent or 1, 10, 100, or 500 mg/kg melatonin. Ten minutes later control animals were injected with saline, and the experimental group with LPS.</p><p><strong>Main outcome measures: </strong>Mesenteric blood flow and serum TNFalpha concentration.</p><p><strong>Results: </strong>In control animals, 100 and 500 mg/kg melatonin reduced MBF. LPS reduced MBF in solvent, 1, and 10 mg/kg melatonin groups. The concentration of TNFalpha was considerably increased in the mice given LPS. Melatonin reduced this response significantly.</p><p><strong>Conclusion: </strong>In high doses melatonin directly reduces MBF. It has no protective effect on the LPS-induced decrease in MBF. In lower doses it blocks, but at higher doses reduces, LPS-induced TNFalpha production.</p>","PeriodicalId":22411,"journal":{"name":"The European journal of surgery = Acta chirurgica","volume":"166 9","pages":"722-7"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/110241500750008484","citationCount":"35","resultStr":"{\"title\":\"Melatonin modulates mesenteric blood flow and TNFalpha concentrations after lipopolysaccharide challenge.\",\"authors\":\"A Baykal, A B Iskit, E Hamaloglu, M O Guc, G Hascelik, I Sayek\",\"doi\":\"10.1080/110241500750008484\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the effect of various doses of melatonin on reduction in mesenteric blood flow (MBF) and increase in tumour necrosis factor alpha (TNFalpha) concentration caused by injection of lipopolysaccharide (LPS).</p><p><strong>Design: </strong>University Hospital, Turkey.</p><p><strong>Setting: </strong>Open experimental study.</p><p><strong>Animals: </strong>59 Swiss albino mice.</p><p><strong>Interventions: </strong>Animals were injected with melatonin solvent or 1, 10, 100, or 500 mg/kg melatonin. Ten minutes later control animals were injected with saline, and the experimental group with LPS.</p><p><strong>Main outcome measures: </strong>Mesenteric blood flow and serum TNFalpha concentration.</p><p><strong>Results: </strong>In control animals, 100 and 500 mg/kg melatonin reduced MBF. LPS reduced MBF in solvent, 1, and 10 mg/kg melatonin groups. The concentration of TNFalpha was considerably increased in the mice given LPS. Melatonin reduced this response significantly.</p><p><strong>Conclusion: </strong>In high doses melatonin directly reduces MBF. It has no protective effect on the LPS-induced decrease in MBF. In lower doses it blocks, but at higher doses reduces, LPS-induced TNFalpha production.</p>\",\"PeriodicalId\":22411,\"journal\":{\"name\":\"The European journal of surgery = Acta chirurgica\",\"volume\":\"166 9\",\"pages\":\"722-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/110241500750008484\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The European journal of surgery = Acta chirurgica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/110241500750008484\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The European journal of surgery = Acta chirurgica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/110241500750008484","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Melatonin modulates mesenteric blood flow and TNFalpha concentrations after lipopolysaccharide challenge.
Objective: To investigate the effect of various doses of melatonin on reduction in mesenteric blood flow (MBF) and increase in tumour necrosis factor alpha (TNFalpha) concentration caused by injection of lipopolysaccharide (LPS).
Design: University Hospital, Turkey.
Setting: Open experimental study.
Animals: 59 Swiss albino mice.
Interventions: Animals were injected with melatonin solvent or 1, 10, 100, or 500 mg/kg melatonin. Ten minutes later control animals were injected with saline, and the experimental group with LPS.
Main outcome measures: Mesenteric blood flow and serum TNFalpha concentration.
Results: In control animals, 100 and 500 mg/kg melatonin reduced MBF. LPS reduced MBF in solvent, 1, and 10 mg/kg melatonin groups. The concentration of TNFalpha was considerably increased in the mice given LPS. Melatonin reduced this response significantly.
Conclusion: In high doses melatonin directly reduces MBF. It has no protective effect on the LPS-induced decrease in MBF. In lower doses it blocks, but at higher doses reduces, LPS-induced TNFalpha production.
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