{"title":"过氧化氢对卵清蛋白致敏大鼠气管肌乙酰胆碱收缩作用增强。","authors":"C Mederle, F Schneider","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ten Sprague-Dawley male rats were sensitised with ovalbumin. The effect of hydrogen peroxide on the constrictor effect of acetylcholine was studied in the isolated tracheal muscle. Preincubation with hydrogen peroxide (H2O2) 10(-3) M (1 min/30 min) does not modify the acetylcholine constrictor effect in the control group. Ovalbumin sensitisation enhanced the acetylcholine constrictor effect (mean value of 19%) irrespective of dosage, comparatively with the control group. Short- and long-term preincubation with hydrogen peroxide enhanced the acetylcholine effect in the sensitised group, irrespective of dosage, comparatively with the control group. A relationship between dosage, contractile response and time of incubation was noticed only in the sensitised group.</p>","PeriodicalId":79373,"journal":{"name":"Romanian journal of physiology : physiological sciences","volume":"36 1-2","pages":"87-90"},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acetylcholine constrictor effect enhanced by hydrogen peroxide in ovalbumin-sensitised rat tracheal muscle.\",\"authors\":\"C Mederle, F Schneider\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ten Sprague-Dawley male rats were sensitised with ovalbumin. The effect of hydrogen peroxide on the constrictor effect of acetylcholine was studied in the isolated tracheal muscle. Preincubation with hydrogen peroxide (H2O2) 10(-3) M (1 min/30 min) does not modify the acetylcholine constrictor effect in the control group. Ovalbumin sensitisation enhanced the acetylcholine constrictor effect (mean value of 19%) irrespective of dosage, comparatively with the control group. Short- and long-term preincubation with hydrogen peroxide enhanced the acetylcholine effect in the sensitised group, irrespective of dosage, comparatively with the control group. A relationship between dosage, contractile response and time of incubation was noticed only in the sensitised group.</p>\",\"PeriodicalId\":79373,\"journal\":{\"name\":\"Romanian journal of physiology : physiological sciences\",\"volume\":\"36 1-2\",\"pages\":\"87-90\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian journal of physiology : physiological sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian journal of physiology : physiological sciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
10只Sprague-Dawley雄性大鼠用卵清蛋白致敏。在离体气管肌肉中研究了过氧化氢对乙酰胆碱收缩作用的影响。在对照组中，过氧化氢(H2O2) 10(-3) M (1 min/30 min)预孵育不改变乙酰胆碱收缩效应。与对照组相比，卵清蛋白致敏增强了乙酰胆碱收缩效应(平均值19%)，与剂量无关。与对照组相比，不论剂量如何，短期和长期过氧化氢预孵育均增强了敏化组的乙酰胆碱作用。剂量、收缩反应和孵育时间之间的关系仅在敏感组被注意到。
Acetylcholine constrictor effect enhanced by hydrogen peroxide in ovalbumin-sensitised rat tracheal muscle.
Ten Sprague-Dawley male rats were sensitised with ovalbumin. The effect of hydrogen peroxide on the constrictor effect of acetylcholine was studied in the isolated tracheal muscle. Preincubation with hydrogen peroxide (H2O2) 10(-3) M (1 min/30 min) does not modify the acetylcholine constrictor effect in the control group. Ovalbumin sensitisation enhanced the acetylcholine constrictor effect (mean value of 19%) irrespective of dosage, comparatively with the control group. Short- and long-term preincubation with hydrogen peroxide enhanced the acetylcholine effect in the sensitised group, irrespective of dosage, comparatively with the control group. A relationship between dosage, contractile response and time of incubation was noticed only in the sensitised group.
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