一种新的木脂素苷类化合物及其它成分。

Sofia Pasi, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Ioanna B Chinou
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引用次数: 22

摘要

从安溴西啶根中分离到新的木脂素糖苷1,5-二羟基-2-(4′- β -d -葡萄糖氨基氧基-3′-甲氧基苯基)-6-(4′-羟基-3′-甲氧基苯基)-3,7-二氧西环[3.3.0]辛烷,命名为安溴西啶(结构:见文),并分离到7个已知化合物(4个环烯醚萜和3个羟基肉桂酯)。这些化合物的结构通过核磁共振和质谱技术以及化学转化来确定。这种新型化合物[结构:见原文]对5种人类实体肿瘤细胞系的细胞毒活性进行了评估。
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A new lignan glycoside and other constituents from Cephalaria ambrosioides.

A new lignan glycoside, 1,5-dihydroxy-2-(4"-beta-D-glucopyranosyloxy-3"-methoxyphenyl)-6-(4'-hydroxy-3'-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, named ambrosidine ([structure: see text]), along with seven known compounds (four iridoids and three hydroxycinnamic esters) were isolated from the roots of Cephalaria ambrosioides. The structures of these compounds were determined by use of NMR and MS techniques and by chemical transformations. The cytotoxic activity of the novel compound [structure: see text] was evaluated against five human solid tumour cell lines.

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A new lignan glycoside and other constituents from Cephalaria ambrosioides. Highly oxygenated triterpenes from the roots of Atropa acuminata. Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola. Separation and identification of Taxifolin 3-O-glucoside isomers from Chamaecyparis obtusa (Cupressaceae). Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.
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