连续16个月服用12 g/天的二十碳五烯酸乙酯对血浆、红细胞和血小板脂肪酸的影响:二高γ γ亚麻酸、花生四烯酸和二十二碳六烯酸及其与因纽特人代谢的相关性。

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-05-01 DOI:10.1016/s0952-3278(03)00007-3

David Horrobin, M Rebecca Fokkema, Frits A J Muskiet

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引用次数: 12

摘要

一位套细胞淋巴瘤患者连续16个月每天服用12g二十碳五烯酸乙酯。血浆、红细胞和血小板中二十碳五烯酸和二十二碳五烯酸水平均高于参考值，但二十二碳六烯酸水平在正常范围内。花生四烯酸水平适度降低，但二异丙甘氨酸水平保持在正常范围内。尽管长链n-3脂肪酸的摄入量高于大多数因纽特人，但该患者的花生四烯酸水平仍明显高于因纽特人。对理解脂肪酸代谢在人类中的意义进行了讨论。

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The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism.

A patient with mantle cell lymphoma took 12g/day of ethyl-eicosapentaenoate for 16 months. Compared to reference values, eicosapentaenoic and docosapentaenoic acids were elevated in plasma, red cells and platelets but docosahexaenoic acid levels were in the normal range. Arachidonic acid levels were moderately reduced but dihomogammalinolenic acid levels remained in the normal range. In spite of a long chain n-3 fatty acid intake higher than in most Inuit populations, arachidonic acid levels remained considerably higher in this patient than in the Inuit. The implications for understanding of fatty acid metabolism in humans are discussed.

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.