{"title":"α-亚麻酸在男性和女性中转化为棕榈酸、棕榈油酸、硬脂酸和油酸","authors":"G.C. Burdge, S.A. Wootton","doi":"10.1016/S0952-3278(03)00111-X","DOIUrl":null,"url":null,"abstract":"<div><div>The purpose of this study was to determine whether adult humans can recycle carbon from <em>α</em>-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700<!--> <!-->mg [U-<sup>13</sup>C]-18:3n-3. Blood was collected over 21 days and breath over 24<!--> <!-->h. [<sup>13</sup><span><span>C]-labelled SFA and MUFA<span> were detected in plasma phosphatidylcholine (PC) and </span></span>triacylglycerol<span> (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [</span></span><sup>13</sup>C]-16:0 was the major labelled fatty acid in both fractions. Total [<sup>13</sup>C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (<em>r</em><sup>2</sup>=0.35,<em>P</em><0.05) to the fractional recovery of labelled 18:3n-3 as <sup>13</sup>CO<sub>2</sub> on breath. These results suggest that the extent of partitioning towards <em>β</em>-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.</div></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"69 4","pages":"Pages 283-290"},"PeriodicalIF":3.2000,"publicationDate":"2003-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women\",\"authors\":\"G.C. Burdge, S.A. Wootton\",\"doi\":\"10.1016/S0952-3278(03)00111-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The purpose of this study was to determine whether adult humans can recycle carbon from <em>α</em>-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700<!--> <!-->mg [U-<sup>13</sup>C]-18:3n-3. Blood was collected over 21 days and breath over 24<!--> <!-->h. [<sup>13</sup><span><span>C]-labelled SFA and MUFA<span> were detected in plasma phosphatidylcholine (PC) and </span></span>triacylglycerol<span> (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [</span></span><sup>13</sup>C]-16:0 was the major labelled fatty acid in both fractions. Total [<sup>13</sup>C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (<em>r</em><sup>2</sup>=0.35,<em>P</em><0.05) to the fractional recovery of labelled 18:3n-3 as <sup>13</sup>CO<sub>2</sub> on breath. These results suggest that the extent of partitioning towards <em>β</em>-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.</div></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":\"69 4\",\"pages\":\"Pages 283-290\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2003-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S095232780300111X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2003/8/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S095232780300111X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2003/8/1 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women
The purpose of this study was to determine whether adult humans can recycle carbon from α-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-13C]-18:3n-3. Blood was collected over 21 days and breath over 24 h. [13C]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [13C]-16:0 was the major labelled fatty acid in both fractions. Total [13C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r2=0.35,P<0.05) to the fractional recovery of labelled 18:3n-3 as 13CO2 on breath. These results suggest that the extent of partitioning towards β-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
