Abdulaziz Anas , Jeladhara Sobhanan , K.M. Sulfiya , C. Jasmin , P.K. Sreelakshmi , Vasudevanpillai Biju
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Advances in photodynamic antimicrobial chemotherapy
Photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) combine light and photosensitizers to treat cancers and microbial infections, respectively. In PACT, the excitation of a photosensitizer drug with appropriate light generates reactive oxygen species (ROS) that kill pathogens in the proximity of the drug. PACT has considerably advanced with new light sources, biocompatible photosensitizers, bioconjugate methods, and efficient ROS production. The PACT technology has evolved to compete with or replace antibiotics, reducing the burden of antibiotic resistance. This review updates recent advances in PACT, with special references to light sources, photosensitizers, and emerging applications to microbial infestations. We also discuss PACT applied to COVID-19 causing SARS-CoV-2 treatment and disinfecting food materials and water. Finally, we discuss the pathogen selectivity and efficiency of PACT.
期刊介绍：
The Journal of Photochemistry and Photobiology C: Photochemistry Reviews, published by Elsevier, is the official journal of the Japanese Photochemistry Association. It serves as a platform for scientists across various fields of photochemistry to communicate and collaborate, aiming to foster new interdisciplinary research areas. The journal covers a wide scope, including fundamental molecular photochemistry, organic and inorganic photochemistry, photoelectrochemistry, photocatalysis, solar energy conversion, photobiology, and more. It provides a forum for discussing advancements and promoting collaboration in the field of photochemistry.
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