人α-脂蛋白与红细胞之间的脂质转移

Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects Pub Date : 1964-04-20 DOI:10.1016/0926-6542(64)90075-7

L.A.E. Ashworth, C. Green

{"title":"人α-脂蛋白与红细胞之间的脂质转移","authors":"L.A.E. Ashworth, C. Green","doi":"10.1016/0926-6542(64)90075-7","DOIUrl":null,"url":null,"abstract":"<div><ul><li>1.1. The transfer of palmitic acid and sterol between human α-lipoprotein and erythrocytes has been studied.</li><li>2.2. Human erythrocytes take up palmitic acid from α-lipoprotein until all binding sites are filled. The process is very much more rapid if the lipoprotein also extra cholesterol.</li><li>3.3. 38% of the endotenous unesterified sterol of human α-lipoprotein does not exchange with that of rat erythrocytes.</li><li>4.4. [14C]Cholesterol taken up by the lipoprotein after dispersion on Celite exchanges with that of human erythrocytes but it does not behave in exactly the same way as the endogenous sterol.</li><li>5.5. When α-lipoprotein is labelled with both cholesterol and palmitic acid and then incubated with human erythrocytes, each interferes with the transfer, to the cells, of the other.</li></ul></div>","PeriodicalId":100171,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","volume":"84 2","pages":"Pages 182-187"},"PeriodicalIF":0.0000,"publicationDate":"1964-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6542(64)90075-7","citationCount":"30","resultStr":"{\"title\":\"The transfer of lipids between human α-lipoprotein and erythrocytes\",\"authors\":\"L.A.E. Ashworth, C. Green\",\"doi\":\"10.1016/0926-6542(64)90075-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><ul><li>1.1. The transfer of palmitic acid and sterol between human α-lipoprotein and erythrocytes has been studied.</li><li>2.2. Human erythrocytes take up palmitic acid from α-lipoprotein until all binding sites are filled. The process is very much more rapid if the lipoprotein also extra cholesterol.</li><li>3.3. 38% of the endotenous unesterified sterol of human α-lipoprotein does not exchange with that of rat erythrocytes.</li><li>4.4. [14C]Cholesterol taken up by the lipoprotein after dispersion on Celite exchanges with that of human erythrocytes but it does not behave in exactly the same way as the endogenous sterol.</li><li>5.5. When α-lipoprotein is labelled with both cholesterol and palmitic acid and then incubated with human erythrocytes, each interferes with the transfer, to the cells, of the other.</li></ul></div>\",\"PeriodicalId\":100171,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects\",\"volume\":\"84 2\",\"pages\":\"Pages 182-187\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6542(64)90075-7\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926654264900757\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926654264900757","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 30

摘要

1.1. 研究了棕榈酸和甾醇在人α-脂蛋白和红细胞之间的转移。人红细胞从α-脂蛋白中吸收棕榈酸，直到所有结合位点都被填满。如果脂蛋白也含有额外的胆固醇，这个过程会迅速得多。4.4.人α-脂蛋白内源性未酯化甾醇38%与大鼠红细胞不交换。[14C]在Celite上分散后，脂蛋白所吸收的胆固醇与人红细胞的胆固醇交换，但其行为方式与内源性固醇不完全相同。当α-脂蛋白同时贴上胆固醇和棕榈酸的标签，然后与人红细胞一起培养时，两者都会干扰另一方向细胞的转移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The transfer of lipids between human α-lipoprotein and erythrocytes

1.
1. The transfer of palmitic acid and sterol between human α-lipoprotein and erythrocytes has been studied.
2.
2. Human erythrocytes take up palmitic acid from α-lipoprotein until all binding sites are filled. The process is very much more rapid if the lipoprotein also extra cholesterol.
3.
3. 38% of the endotenous unesterified sterol of human α-lipoprotein does not exchange with that of rat erythrocytes.
4.
4. [¹⁴C]Cholesterol taken up by the lipoprotein after dispersion on Celite exchanges with that of human erythrocytes but it does not behave in exactly the same way as the endogenous sterol.
5.
5. When α-lipoprotein is labelled with both cholesterol and palmitic acid and then incubated with human erythrocytes, each interferes with the transfer, to the cells, of the other.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助