抗氧化苦参外泌体包被水凝胶通过调节氧化应激微环境促进脊髓修复

IF 4.7 4区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 DOI:10.1016/j.nano.2022.102625
Jiachen Chen B.S. , Jiahe Wu Ph.D. , Jiafu Mu B.S. , Liming Li Ph.D. , Jingyi Hu B.S. , Hangjuan Lin M.D. , Jian Cao M.D. , Jianqing Gao Ph.D.
{"title":"抗氧化苦参外泌体包被水凝胶通过调节氧化应激微环境促进脊髓修复","authors":"Jiachen Chen B.S. ,&nbsp;Jiahe Wu Ph.D. ,&nbsp;Jiafu Mu B.S. ,&nbsp;Liming Li Ph.D. ,&nbsp;Jingyi Hu B.S. ,&nbsp;Hangjuan Lin M.D. ,&nbsp;Jian Cao M.D. ,&nbsp;Jianqing Gao Ph.D.","doi":"10.1016/j.nano.2022.102625","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Spinal cord injury<span> (SCI) is a severe traumatic disease because of its complications and multi-organ dysfunction. After the injury, the disruption of microenvironment </span></span>homeostasis in the lesion demolishes the surrounding healthy tissues </span><em>via</em><span><span> various pathways. The microenvironment regulation is beneficial for neural and functional recovery. Sustained release, cellular uptake, and long-term retention of therapeutic molecules at the impaired sites are important for continuous microenvironment improvement. In our study, a local-implantation system was constructed for SCI </span>treatment<span> by encapsulating exosomes derived from </span></span><em>Flos Sophorae Immaturus</em><span><span><span><span><span> (so-exos) in a polydopamine-modified hydrogel (pDA-Gel). So-exos are used as nanoscale natural vehicles of </span>rutin, a </span>flavonoid </span>phytochemical that is effective in microenvironment improvement and </span>nerve regeneration. Our study showed that the pDA-Gel-encapsulated so-exos allowed rapid improvement of the impaired motor function and alleviation of urination dysfunction by modulating the spinal inflammatory and oxidative conditions, thus illustrating a potential SCI treatment through a combinational delivery of so-exos.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"47 ","pages":"Article 102625"},"PeriodicalIF":4.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment\",\"authors\":\"Jiachen Chen B.S. ,&nbsp;Jiahe Wu Ph.D. ,&nbsp;Jiafu Mu B.S. ,&nbsp;Liming Li Ph.D. ,&nbsp;Jingyi Hu B.S. ,&nbsp;Hangjuan Lin M.D. ,&nbsp;Jian Cao M.D. ,&nbsp;Jianqing Gao Ph.D.\",\"doi\":\"10.1016/j.nano.2022.102625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Spinal cord injury<span> (SCI) is a severe traumatic disease because of its complications and multi-organ dysfunction. After the injury, the disruption of microenvironment </span></span>homeostasis in the lesion demolishes the surrounding healthy tissues </span><em>via</em><span><span> various pathways. The microenvironment regulation is beneficial for neural and functional recovery. Sustained release, cellular uptake, and long-term retention of therapeutic molecules at the impaired sites are important for continuous microenvironment improvement. In our study, a local-implantation system was constructed for SCI </span>treatment<span> by encapsulating exosomes derived from </span></span><em>Flos Sophorae Immaturus</em><span><span><span><span><span> (so-exos) in a polydopamine-modified hydrogel (pDA-Gel). So-exos are used as nanoscale natural vehicles of </span>rutin, a </span>flavonoid </span>phytochemical that is effective in microenvironment improvement and </span>nerve regeneration. Our study showed that the pDA-Gel-encapsulated so-exos allowed rapid improvement of the impaired motor function and alleviation of urination dysfunction by modulating the spinal inflammatory and oxidative conditions, thus illustrating a potential SCI treatment through a combinational delivery of so-exos.</span></p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":\"47 \",\"pages\":\"Article 102625\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963422001113\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963422001113","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 6

摘要

脊髓损伤是一种严重的外伤性疾病,其并发症多,多器官功能紊乱。损伤后,病变微环境稳态的破坏通过多种途径破坏周围的健康组织。微环境调节有利于神经和功能的恢复。持续释放、细胞摄取和治疗分子在受损部位的长期保留对于持续的微环境改善是重要的。在我们的研究中,通过将来自Sophorae Immaturus (so-exos)的外泌体包埋在聚多巴胺修饰的水凝胶(da - gel)中,构建了局部植入系统来治疗SCI。so -exo被用作芦丁的纳米级天然载体,芦丁是一种黄酮类植物化学物质,在微环境改善和神经再生中有效。我们的研究表明,pda凝胶包封的so-exos可以通过调节脊柱炎症和氧化条件来快速改善受损的运动功能和减轻排尿功能障碍,从而表明通过联合递送so-exos可能治疗SCI。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment

Spinal cord injury (SCI) is a severe traumatic disease because of its complications and multi-organ dysfunction. After the injury, the disruption of microenvironment homeostasis in the lesion demolishes the surrounding healthy tissues via various pathways. The microenvironment regulation is beneficial for neural and functional recovery. Sustained release, cellular uptake, and long-term retention of therapeutic molecules at the impaired sites are important for continuous microenvironment improvement. In our study, a local-implantation system was constructed for SCI treatment by encapsulating exosomes derived from Flos Sophorae Immaturus (so-exos) in a polydopamine-modified hydrogel (pDA-Gel). So-exos are used as nanoscale natural vehicles of rutin, a flavonoid phytochemical that is effective in microenvironment improvement and nerve regeneration. Our study showed that the pDA-Gel-encapsulated so-exos allowed rapid improvement of the impaired motor function and alleviation of urination dysfunction by modulating the spinal inflammatory and oxidative conditions, thus illustrating a potential SCI treatment through a combinational delivery of so-exos.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
8.10
自引率
3.60%
发文量
104
审稿时长
4.6 months
期刊介绍: Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
期刊最新文献
State-of-the-art and future perspectives in infertility diagnosis: Conventional versus nanotechnology-based assays Fabrication of blended nanofibrous cardiac patch transplanted with TGF-β3 and human umbilical cord MSCs-derived exosomes for potential cardiac regeneration after acute myocardial infarction Delivery of gene editing therapeutics Liposomes - Human phagocytes interplay in whole blood: effect of liposome design Coating influence on inner shell water exchange: An underinvestigated major contributor to SPIONs relaxation properties
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1