神经节苷脂胶束的研究

Robert E. Howard, Robert Main Burton
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引用次数: 46

摘要

通过蒸汽压下降法测定了β-神经节苷脂在不同溶剂中的分子量。分子质量接近1665,对应于含有鞘氨醇、硬脂酸、葡萄糖、半乳糖、n -乙酰半乳糖胺和两个n -乙酰神经氨酸残基的结构。在水溶液中,神经节苷脂结合形成胶束结构,总重量为200000或更大。发现临界胶束浓度为1.0·10−5 m,并对这些性质进行了讨论。
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Studies on the ganglioside micelle

The molecular weight of β-ganglioside was measured by vapor pressure depression in a number of different solvents. The molecular weight was found to be near 1665, corresponding to a structure containing sphingosine, stearic acid, glucose, galactose, N-acetylgalactosamine, and two N-acetylneuraminic acid residues. In aqueous solution, the ganglioside associated to form a micelle structure with an aggregate weight of 200 000 or greater. The critical micelle concentration was found to be 1.0 · 10−5 M. A discussion of these properties is presented.

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