毛细管电泳法测定马兜铃酸。

Horacio A Priestap, Silvia L Iglesias, Martín F Desimone, Luis E Diaz
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引用次数: 0

摘要

介绍了一种毛细管电泳分离定量马兜铃酸的方法。以pH 6.5 ~ 7的磷酸二氢钠、硼酸钠和十二烷基硫酸钠为缓冲溶液,可以很好地分离马兜铃酸。一种名为charrua的商业酊剂(一种由阿根廷马兜铃水醇提取物组成的传统草药)中所含的六种马兜铃酸的分离和鉴定证实了该方法的有效性。讨论了含马兜铃酸的沙参酊剂的最终毒性。
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Determination of aristolochic acids by capillary electrophoresis.

A method for the separation and quantification of aristolochic acids by capillary electrophoresis is described. Buffer solutions composed of sodium dihydrogen phosphate, sodium borate, and sodium dodecyl sulfate at pH 6.5-7 were found to be suitable for the separation of aristolochic acids, which can be well resolved in a few minutes. The separation and identification of six aristolochic acids contained in a commercial tincture called charrua, a traditional herbal medicine consisting of a hydroalcoholic extract of Aristolochia argentina, corroborate the usefulness of the method. The eventual toxic properties of the aristolochic acid containing charrua tincture are discussed.

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