慢性莱姆病成功治疗后特异性免疫反应消失

Dieter Hassler , Matthias Schnauffer , Hans Ehrfeld , Elke Müller
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引用次数: 7

摘要

根据一项对照试验的结果制定的标准化治疗方案,对512名连续患有慢性莱姆病的患者进行了治疗(Hassler等人,1990;哈斯勒,1992)。随访至少6年(最长16年)。在初始治疗后的前两年,每六个月收集一次临床和血清学数据,包括Western blot检测,之后每年收集一次。
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Disappearance of specific immune response after successful therapy of chronic Lyme borreliosis

512 consecutive patients suffering from chronic Lyme borreliosis have been treated according to a standardized therapy regimen which was developed using the results of a controlled trial (Hassler et al., 1990; Hassler, 1992). Follow up was performed for at least 6 (maximum 16) years. In the first two years after initial therapy clinical and serological data were collected every six months including Western blot testing, later once a year.

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Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi Significant improvement of the recombinant Borrelia IgG immunoblot for serodiagnosis of early neuroborreliosis Disappearance of specific immune response after successful therapy of chronic Lyme borreliosis Borrelia burgdorferi s.l. OspA-types are widespread in Bavaria but show distinct local patterns The zoonotic reservoir of Borrelia burgdorferi sensu lato in the Mazury Lakes district of North-Eastern Poland
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