同型半胱氨酸在阿尔茨海默病和血管性痴呆中的作用

IF 3.8 3区 医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2004-01-01 Epub Date: 2004-06-15 DOI:10.1016/j.archger.2004.04.027
M. GALLUCCI , A. ZANARDO , L. DE VALENTIN , A. VIANELLO
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引用次数: 0

摘要

高同型半胱氨酸血症是动脉粥样硬化的重要危险因素,最近被认为是阿尔茨海默病(AD)的诊断标志。目前的研究比较了AD和血管性痴呆(VD)患者以及对照组的同型半胱氨酸血症。在137例按照NINCDS-ADRDA标准诊断的疑似AD患者、40例按照nincds - airen标准诊断的疑似VD患者和42例对照受试者中检测了同型半胱氨酸血症。AD和VD组的同型半胱氨酸水平明显高于对照组,然而,VD患者的年龄明显大于对照组。与对照组相比,女性在AD组中的比例更高,而AD组和VD组的血清叶酸和B12水平往往更低。为了调整这些潜在干扰因素的结果,进行了多变量ANCOVA计算,其中考虑2个分组因素(性别和神经类型)和4个协变量(年龄、白蛋白、血清叶酸和维生素B12)分析同型半胱氨酸水平。该分析证实,即使在调整协变量后,AD和VD组与对照组之间的差异仍然非常显著,而性别本身以及性别与神经类型的相互作用对同型半胱氨酸水平没有任何显著影响。因此,主要的发现是,与对照组相比,这两种疾病组的同型半胱氨酸水平显著增加。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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