迭代I型聚酮合成酶的结构酶学:催化编程的各种途径

IF 10.2 1区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-08-15 DOI:10.1039/D3NP00015J
Jialiang Wang, Zixin Deng, Jingdan Liang and Zhijun Wang
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引用次数: 0

摘要

迭代型I型聚酮合成酶(iPKSs)是杰出的天然化学家,是一种重复利用其催化结构域合成具有多种生物活性的复杂天然产物的巨型酶。也许关于I型ipks最令人着迷但又最不为人所知的问题是,它们是如何在合成周期中执行迭代的程序化反应的,在这种反应中,结构域组合的使用是不同的。编程模式由多种因素实现,并强烈影响最终自然产物的复杂性。本文回顾了iPKSs结构酶学方面的报告,重点介绍了单个结构域结构,然后重点介绍了每个结构域可能贡献的代表性编程活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

Time span of literature covered: up to mid-2023

Iterative type I polyketide synthases (iPKSs) are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic domains to synthesize complex natural products with diverse bioactivities. Perhaps the most fascinating but least understood question about type I iPKSs is how they perform the iterative yet programmed reactions in which the usage of domain combinations varies during the synthetic cycle. The programmed patterns are fulfilled by multiple factors, and strongly influence the complexity of the resulting natural products. This article reviews selected reports on the structural enzymology of iPKSs, focusing on the individual domain structures followed by highlighting the representative programming activities that each domain may contribute.

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来源期刊
Natural Product Reports
Natural Product Reports 化学-生化与分子生物学
CiteScore
21.20
自引率
3.40%
发文量
127
审稿时长
1.7 months
期刊介绍: Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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