LPS诱导小鼠原代培养的胶质细胞中stefin A3的表达

Molecular Brain Research Pub Date : 2005-10-31 DOI:10.1016/j.molbrainres.2005.07.007

Toru Hosoi , Sawako Suzuki , Yasunobu Okuma , Akiko Kawakami , Naoki Ogawa , Koichiro Ozawa , Yasuyuki Nomura

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引用次数: 4

摘要

我们在原代培养的胶质细胞中寻找一种基因，该基因在较晚的时间点对LPS的反应中上调。使用基因芯片探针阵列，我们鉴定了stefin A3，这是一种已知的半胱氨酸蛋白酶抑制剂。通过RT-PCR评估，我们观察到stefin A3的时间依赖性(2至48 h)上调。结果表明，steina3在较晚的时间点参与了感染和炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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LPS induces stefin A3 expression in mouse primary cultured glial cells

We searched for a gene that is up-regulated in response to LPS at a later time point in primary cultured glial cells. Using a Gene Chip Probe Array, we identified stefin A3, which is known as a cysteine protease inhibitor. As assessed by RT-PCR, we observed a time-dependent (2 to 48 h) up-regulation of stefin A3. The results indicate that stefin A3 is involved in infection and inflammation at a later time point.

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Molecular Brain Research

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