[安非他酮作用期间(抑郁症)多巴胺转运蛋白活性(DAT)的变化]。

Q3 Pharmacology, Toxicology and Pharmaceutics Neuropsychopharmacologia Hungarica Pub Date : 2004-06-01

Zoltán Szabó, Miklós Argyelán, Balázs Kanyó, László Pávics, Zoltán Janka

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引用次数: 0

摘要

安非他酮通过阻断多巴胺转运体具有抗抑郁作用。通过99mTc-TRODAT-SPECT，我们测量了抑郁症患者的基线DAT活动。安非他酮治疗3周后，我们研究了DAT活性的变化，这与安非他酮的占用相对应。安非他酮在9例抑郁症患者DAT中的平均使用率为20.84%，与国际研究结果相似。

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[Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)].

Bupropion has an antidepressant effect through blocking the dopamine transporter. By 99mTc-TRODAT-SPECT, we measured the baseline DAT activity of depressed patients. After 3 weeks' bupropion treatment we studied the change in DAT activity, which corresponds to the occupancy of bupropion. The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.

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来源期刊

Neuropsychopharmacologia Hungarica Medicine-Medicine (all)

CiteScore

1.60

自引率

0.00%

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