20次全身冷冻刺激后II级肥胖青年男性血液促氧化剂/抗氧化剂平衡:一项初步研究

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2021-12-01 DOI:10.1080/13510002.2021.1881328
Wanda Pilch, Joanna Wyrostek, Anna Piotrowska, Olga Czerwińska-Ledwig, Roxana Zuziak, Ewa Sadowska-Krępa, Marcin Maciejczyk, Małgorzata Żychowska
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引用次数: 10

摘要

目的:在肥胖中,促氧化-抗氧化平衡向氧化反应转变。然而,研究表明,在身体成分正常的人群中,经过一系列全身冷冻疗法(WBC)后,平衡向相反的方向转移。设计:本研究的目的是评估20种白细胞治疗对血液促氧化-抗氧化平衡的影响。干预措施:研究包括14名肥胖(BMI > 35)和10名非肥胖志愿者。方法:在末次冷冻刺激1 h和2 h后测定大鼠血清总抗氧化活性(TAS/TAC)、促氧化活性(TOS/TOC)和红细胞抗氧化酶活性。结果:肥胖组TOS/TOC水平明显升高,WBC系列检查后TOS/TOC水平明显降低。冷冻治疗对两组患者TAS/TAC水平无影响,差异无统计学意义。抗氧化酶活性的变化是多向的。观察到肥胖组的CAT活性增加。在一系列治疗之前和之后,肥胖受试者的OSI明显更高。结论:提示对TOS/TOC水平和CAT活性有有益的影响,但对II类肥胖患者提出的治疗数量不足。试验注册:澳大利亚新西兰临床试验注册标识:ACTRN12619000524190。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Blood pro-oxidant/antioxidant balance in young men with class II obesity after 20 sessions of whole body cryostimulation: a preliminary study.

Objectives: In obesity, there is a shift in the pro-oxidative-antioxidant balance towards the oxidationreactions. However, it has been shown that in people with normal body composition, after a series of whole-body cryotherapy (WBC), the balance shifts in the opposite direction. Design: The aim of the study was to assess the impact of 20 WBC treatments on blood pro-oxidative-antioxidant balance. Interventions: Study included 14 obese (BMI > 35) and 10 non-obese volunteers. Methods: The total antioxidative (TAS/TAC) and pro-oxidative status (TOS/TOC) in serum and activity of antioxidant enzymes in erythrocytes were determined before the first and 2 hours after the last cryostimulation. Results: In the obese group, a significantly higher level of TOS/TOC, and its significant decrease after the WBC series, was observed. Cryotherapy had no influence on TAS/TAC level which was similar in both groups. Changes in activity of antioxidant enzymes were multidirectional. An increase in CAT activity in the obese group was observed. OSI, both before and after a series of treatments, was significantly higher in obese subjects. Conclusions: A beneficial effect on the level of TOS/TOC and CAT activity was indicated, but the proposed number of treatments for patients with class II obesity turned out to be insufficient. Trial registration: Australian New Zealand Clinical Trials Registry identifier: ACTRN12619000524190.

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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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