与HPV-6相关的颞骨施耐德乳头状瘤恶变

IF 0.4 Q4 OTORHINOLARYNGOLOGY Case Reports in Otolaryngology Pub Date : 2021-01-25 eCollection Date: 2021-01-01 DOI:10.1155/2021/6684254
O Marzouk, F Brasch, I Todt, P K C Goon, H Sudhoff
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引用次数: 0

摘要

简介颞骨施耐德乳头状瘤(TBSPs)很少作为原发性肿瘤出现在中耳和乳突。颞骨施奈德乳头状瘤的临床表现和影像学检查并不具有特异性。因此,只有通过组织病理学检查才能明确诊断:报告一例与 HPV-6 相关的 TBSP 恶性转化的新病例,并介绍其治疗方法。病例报告。一名 68 岁的女性患者出现传导性听力损失和反复右侧耳鸣。起初,我们进行了颞骨外侧切除术,并用腹部脂肪进行阻塞。早期组织学描述为与 HPV-6 相关的 TBSP。随访发现,施奈德乳头状瘤变体发生了恶性转化。术后放疗结合扩大的颞骨切除术使患者在 17 个月的随访中无疾病发生。讨论。TBSP的特异性不强,只有通过组织病理学才能可靠确诊。由于缺乏可靠的预后指标,术后必须进行严格的随访,包括定期进行耳镜检查、鼻内镜检查和影像学检查。本病例也证明了扩大颞骨切除术作为挽救手术的重要性,将根治性手术与放疗相结合可提高存活率。
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Malignant Transformation of Temporal Bone Schneiderian Papilloma Associated with HPV-6.

Introduction: Temporal bone Schneiderian papillomas (TBSPs) rarely present as a primary tumors arising from the middle ear and mastoid process. The clinical findings and imaging of TBSPs are not specific. Therefore, diagnosis can only reliably be definitively established by histopathology.

Objective: To report a novel case of a malignant transformation of TBSP associated with HPV-6 and to present its management. Case Report. A 68-year-old woman presented with conductive hearing loss and recurrent right-sided otorrhoea. Initially, we performed a lateral temporal bone resection and obliteration with abdomen fat. Early histology described TBSP associated with HPV-6. Follow-up detected malignant transformation of the Schneiderian papillomatous variant. Postoperative radiotherapy combined with extended temporal bone resection resulted in a disease-free 17-month period of follow-up. Discussion. TBSPs are not very specific, and the diagnosis can only reliably be established by histopathology. There is a risk of malignant transformation, and due to the absence of reliable prognostic markers, strict postoperative follow-up is mandatory and should consist of regular otoscopy, nasal endoscopy, and imaging. This case also supports the importance of extended temporal bone resections as salvage surgery, combining radical surgery with radiotherapy for improved survival rates.

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来源期刊
Case Reports in Otolaryngology
Case Reports in Otolaryngology OTORHINOLARYNGOLOGY-
自引率
0.00%
发文量
20
审稿时长
13 weeks
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