评价视网膜层厚度参数作为生物标志物在现实世界多发性硬化症队列。

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2021-03-12 eCollection Date: 2021-01-01 DOI:10.2147/EB.S295610
Natascha Schurz, Lydia Sariaslani, Patrick Altmann, Fritz Leutmezer, Christoph Mitsch, Berthold Pemp, Paulus Rommer, Tobias Zrzavy, Thomas Berger, Gabriel Bsteh
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引用次数: 14

摘要

目的:通过光学相干断层扫描(OCT)测量视网膜层厚度参数是多发性硬化症(MS)神经轴突变性和炎症的新兴生物标志物。我们的目的是评估视网膜层厚度在现实世界MS队列中预测残疾恶化和复发的价值。患者和方法:在这项纵向观察性研究中,我们纳入了谱域OCT扫描可用且临床随访≥1年的MS患者。采用多变量模型检验观察期内乳头周围视网膜神经纤维层(pRNFL)、黄斑神经节细胞-内丛层(GCIPL)和内核层(INL)厚度对残疾恶化和复发的预测价值。结果:我们分析了60例MS患者,平均观察时间为2.9年(SD 1.8)。GCIPL较低的基线厚度(截止值为1.5 μ m/年)与残疾恶化的可能性较高相关(HR分别为5.7,p=0.009和HR 6.8, p=0.003)。复发患者的INL平均增厚0.9µm,而未复发患者的INL平均变薄0.3µm (p=0.04)。在多变量分析中,INL增厚与复发概率增加相关(OR 17.8, p=0.023)。结论:GCIPL和pRNFL变薄的横断面和纵向测量在现实世界中作为残疾恶化的生物标志物是可靠的。INL厚度的变化是一个很有希望的复发标志,即炎症活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Evaluation of Retinal Layer Thickness Parameters as Biomarkers in a Real-World Multiple Sclerosis Cohort.

Purpose: Retinal layer thickness parameters measured by optical coherence tomography (OCT) are emerging biomarkers of neuroaxonal degeneration and inflammation in multiple sclerosis (MS). We aimed to evaluate the value of retinal layer thickness for prediction of disability worsening and relapse in a real-world MS cohort.

Patients and methods: For this longitudinal observational study, we included MS patients with spectral-domain OCT scans available and ≥1 year of clinical follow-up. The value of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion-cell-and-inner-plexiform-layer (GCIPL) and inner nuclear layer (INL) thickness for prediction of disability worsening and relapse during the observation period was tested by multivariate models.

Results: We analyzed 60 MS patients during a mean observation period of 2.9 years (SD 1.8). Lower baseline thickness of GCIPL (cut-off <77µm; HR 4.1, p=0.001) and pRNFL (cut-off ≤88µm; HR 3.1, p=0.019) were associated with an increased risk of disability worsening. Longitudinally, mean thinning rates were -0.8µm/year (SD 1.6) for GCIPL, -0.6µm/year (SD 3.5) for pRNFL. GCIPL thinning ≥1.0µm/year and pRNFL >1.5µm/year is associated with higher likelihood of disability worsening (HR 5.7, p=0.009 and HR 6.8, p=0.003, respectively). INL thickened in patients with relapse by a mean 0.9µm while thinning by 0.3µm in patients without relapse (p=0.04). In multivariate analyses, INL thickening was associated with an increased probability of relapse (OR 17.8, p=0.023).

Conclusion: Cross-sectional and longitudinal measurement of GCIPL and pRNFL thinning is reliable as a biomarker of disability worsening in a real-world setting. Change of INL thickness is a promising marker of relapse, i.e. inflammatory activity.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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