Muhtesem Gedizlioglu, Asli Koskderelioglu, Melike Vural, Irem Bedile Tiftikcioglu
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引用次数: 1
摘要
目的:在多发性硬化症(MS)急性复发期间,身体症状引起了极大的关注。然而,认知障碍可能构成新复发的重要部分。在这项研究中,我们评估了MS患者在急性复发期间的认知状态。材料和方法:入选35例明确的多发性硬化症患者和21例健康受试者。在皮质类固醇治疗前和治疗3个月后分别对MS患者进行神经心理测试和事件相关电位P300。对照组只接受了一次测试。结果:在复发期和缓解期,定时25英尺步行测试、简短可重复电池亚测试(10/36 SPART、SDMT、SRT、SRT- ltm)得分差异有统计学意义(p =;005, p =。007, p =。05, p =。029, p =。001年,分别)。复发组P300波潜伏期较缓解组和对照组明显延长(p =。004, p结论:在这项研究中,我们观察到在急性复发中,视觉空间感知、远程记忆和回忆以及P300潜伏期的显著参与。在复发期间纳入认知评估可以为未来的治疗方式提供准确的认知状态信息。
Cognition in acute relapses: A psychometric evaluation and its correlation with event-related potential, P300 in multiple sclerosis.
Objective: During acute relapses of multiple sclerosis (MS), physical symptoms attract utmost care. However, cognitive impairment may constitute an substantial part of a new relapse. In this study, we evaluated the cognitive status of MS patients during acute relapses.
Materials and methods: We enrolled 35 definite MS patients and 21 healthy subjects. Neuropsychometric tests and the event-related potential, P300 were administered to the MS patients before corticosteroid treatment, and 3 months later. The control subjects were tested only once.
Results: The differences between the scores of the Timed 25-Foot Walk test, the Brief Repeatable Battery subtests (10/36 SPART, SDMT, SRT, SRT-LTM) in the relapse and remission phases were statistically significant (p = .005, p = .007, p = .05, p = .029, p = .001, respectively). The latencies of P300 waves during the relapses were significantly prolonged than the ones in the remission and the controls' (p = .004, p < .001, respectively).
Conclusions: In this study, we observed a significant involvement of visual-spatial perception, remote memory, and recall, as well as P300 latencies in acute relapses. The inclusion of cognitive assessment during a relapse can provide accurate information on cognitive status for future treatment modalities.