无牛奶饮食对儿童哮喘控制的影响:一项准实验研究。

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2021-02-15 eCollection Date: 2021-01-01
Sepideh Darougar, Mahboubeh Mansouri, Solmaz Hassani, Mohammad Reza Sohrabi, Paniz Hashemitari
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引用次数: 0

摘要

背景:食物过敏通常发生在生命的第一年,是幼儿持续性哮喘的危险因素。牛奶已被证明是儿童中最常见的食物过敏原。考虑到非ige介导的食物过敏在隐性胃食管反流和哮喘发展中的核心作用,我们评估了消除食物过敏原对更好地控制哮喘的作用。方法:选取Mofid儿童医院哮喘门诊就诊1年的80例12岁以下婴幼儿为研究对象。在治疗2周后哮喘仍未得到控制(儿童哮喘控制试验≤19)的患者中,我们提倡在哮喘常规治疗的基础上进行2周不喝牛奶的饮食。对于母乳喂养的婴儿,要求母亲将这些产品从日常摄入方案中剔除,而对于配方奶喂养的婴儿,则开始使用元素基础配方奶粉。结果:3例患者失访,6例患者因不遵医嘱被排除在研究之外。在整个研究人群中,哮喘控制测试得分低于或等于19分,在我们开始一种基于消除牛奶的饮食后,除13名参与者外,所有参与者的哮喘控制测试得分都增加到20分或更多。结论:总之,结果是有希望的,表明牛奶蛋白消除饮食是治疗顽固性哮喘患者的一种谨慎的方法,可以被认为是哮喘治疗中缺失的环节。
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The effect of a cow's milk-free diet on asthma control in children: a quasi-experimental study.

Background: Food allergy which usually develops in the first year of life is a risk factor for persistent asthma in young children. Cow's milk has been demonstrated to be the most commonly identified food allergen in children. Considering the central role of non-IgE-mediated food allergies in the development of hidden gastroesophageal reflux and consequently asthma, we evaluated the effect of eliminating food allergens to better control asthma.

Method: A total of eighty infants and children up to the age of 12 referred to the Asthma Clinic of Mofid Children Hospital for a period of one year were enrolled in this study. In those patients whose asthma remained uncontrolled (Childhood Asthma Control Test ≤19) despite a 2-week period of treatment, we advocated a 2-week-diet based on eliminating cow's milk in conjunction with asthma conventional therapy. For breast-fed infants, mothers were requested to eliminate these products from their daily intake regimens and for formula-fed infants, the elemental based formula was started.

Results: Three of the patients were lost in follow-up and six of them were excluded from the study because of non-compliance. The Asthma Control Test score which was less than or equal to 19 in the entire study population, increased to 20 or more after we began a diet based on the elimination of cow's milk in all but 13 participants.

Conclusion: To conclude, the results were promising, demonstrating that a cow's milk protein elimination diet is a prudent approach in the management of patients with recalcitrant asthma, and can be considered as the missing link in asthma treatment.

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