[尿碘排泄正常的6-13岁学龄儿童甲状腺大小评价及参考值的可用性仍然适用]。

Adam Kretowski, Małgorzata Brzozowska, Anna Zonenberg, Jacek Borawski, Ida Kinalska
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引用次数: 0

摘要

背景:在分析学龄期儿童甲状腺肿患病率时,甲状腺肿大的评价标准是一个关键问题。回顾文献和自己的经验表明,研究人员对这个问题缺乏共识。同样,在世界卫生组织2001年关于碘缺乏和甲状腺肿大问题的报告中,专家们对生活在饮食中碘供应充足的地区的6-15岁儿童的甲状腺大小超声检查没有提出普遍的参考值,因此建议有必要制定区域规范。目的:本研究的目的是评估在Białystok随机选择的学校6-13岁儿童中甲状腺肿的患病率,并在研究人群中适当补充碘,并估计用于甲状腺大小评估的参考值的可用性。材料和方法:2002年,在Białystok上随机选择了4所小学进行了测试。共有480名6-13岁的儿童参与了这项研究。所有儿童均通过触诊对甲状腺大小进行体格检查,并进行甲状腺USG检查。碘的浓度是在晨尿中测定的。采集血样测定hTSH浓度。结果:在触诊方面,按照2001年WHO标准,研究人群中甲状腺肿的患病率为6.8%。应用1994年世卫组织触诊评估甲状腺肿的标准使这一比例提高到18.2%。当使用世卫组织1997年体表标准由USG评估甲状腺肿大时,其百分比等于7%,而考虑到儿童年龄的参考值,其百分比翻了一番,达到13.5%。当采用Gutekunst等人引入的参考值时,甲状腺肿的百分比增加到45.5%。结论:在评价6-13岁儿童甲状腺肿超声诊断中甲状腺大小时,应用体表和性别(体现儿童实际身体发育)甲状腺大小的参考值似乎比使用日历年龄的参考值更有意义。尽管采取了适当的碘预防措施,但学龄儿童中甲状腺肿的患病率仍高达7%,这表明除碘缺乏外,还有其他因素导致了这一人群的甲状腺肿。
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[Evaluation of the thyroid size among school children aged 6-13 with the normal iodine excretion in the urine and the usability of referential values still applied].

Background: The evaluation criteria of the enlarged thyroid gland becomes a key problem when analyzing the prevalence of goiter in the population of school children. The review of the literature and own experience indicate lack of a consensus concerning this problem among researchers. Similarly, in the report of WHO in the year 2001 concerning the problem of iodine deficit and goiter endemia, experts did not present universal referential values of the thyroid size in ultrasonography for children population aged 6-15 years living in the regions of proper iodine supply in the diet, thus suggesting the necessity of working out regional norms.

Objectives: The aim of the study was to evaluate the prevalence of goiter in children aged 6-13 years from schools chosen randomly in Białystok with proper iodine supplementation in the study population and to estimate the usability of referential values applied in the assessment of the thyroid size.

Material and methods: In the year 2002, the examination was carried out in 4 elementary schools chosen randomly from Białystok. A total of 480 children aged 6-13 years were included in the study. All children were examined physically with palpation assessment of the thyroid size and had USG of the thyroid. The concentration of iodine was measured in the morning urine. The blood samples were collected to determine hTSH concentration.

Results: In palpation, with regard to WHO criteria of the year 2001, the prevalence of goiter was 6.8% in the study population. Applying WHO criteria of 1994 in palpation assessment of goiter increased this percentage up to 18.2%. When using WHO criteria for body surface of 1997 to evaluate goiter by USG, its percentage equaled 7%, whereas taking into consideration referential values for child's age doubled its percentage up to 13.5%. The percentage of goiter increased up to 45.5%, when referential values introduced by Gutekunst et al. were applied.

Conclusions: When evaluating the thyroid size in ultrasonographic diagnostics of goiter in children aged 6-13 years, it seems more purposeful to apply referential values of the thyroid size regarding the body surface and sex (manifesting a child's actual physical development) than to use the norms concerning the calendar age. The prevalence of goiter amounting 7% in the population of school children in spite of adequate iodine prophylaxis suggests other than iodine deficit, factors causing goiter in this population.

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