[儿童和青少年1型糖尿病患者持续皮下注射胰岛素剂量指南]。

Agnieszka Szypowska, Ewa Pańkowska, Maria Lipka
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引用次数: 0

摘要

持续皮下胰岛素输注(CSII)治疗糖尿病已经非常流行,并为糖尿病患者所接受。泵疗法模拟胰岛素的生理分泌,已被证明是一种安全有效的胰岛素给药方法,可替代多次注射的方法。持续胰岛素输注提供了更大的灵活性,在吃饭和零食的时间,更高的治疗满意度。程序化的基础速率可以改善夜间血糖控制,并有助于减少早餐前血糖水平的升高(黎明现象)。此外,CSII可减少运动性和夜间低血糖。胰岛素泵治疗在降低糖化血红蛋白水平方面是有效的,而不会增加严重低血糖和酮症酸中毒的风险。为了通过这种治疗方法实现适当的代谢控制,患者及其家属需要适当的教育,包括饮食管理知识、胰岛素治疗知识和泵装置的手动操作能力。在这里,我们提出了关于胰岛素剂量、基础胰岛素率规划和基于碳水化合物和蛋白质-脂肪交换的膳食丸的一般指导方针。
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[Guidelines concerning insulin dosage in children and adolescents with type 1 diabetes on continuous subcutaneous insulin infusion].

The treatment of diabetes mellitus with a continuous subcutaneous insulin infusion (CSII) has become very popular and is well accepted by diabetic patients. Pump therapy mimics the physiological insulin secretion and has been shown to be a safe and effective method of insulin administration alternative to the method of multiple injections. Continuous insulin infusion provides greater flexibility in the timing of meals and snacks with higher treatment satisfaction. Programmed basal rates improve nocturnal glycemic control and help to minimize a pre-breakfast increase of blood glucose level (the dawn phenomenon). Moreover, CSII can reduce exercise-induced and nocturnal hypoglycemia. Insulin pump therapy is effective in lowering glycated hemoglobin levels without higher risk of severe hypoglycaemia and ketoacidosis. To achieve a proper metabolic control with this method of treatment, the patient and his family requires appropriate education including knowledge of diet management, insulin therapy and manual competence of pump device. Here we present general guidelines for patients education concerning insulin dosage, programming of basal insulin rates and meal boluses based on carbohydrates and protein-fat exchanges.

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[Evaluation of final height in patients with pituitary growth hormone deficiency who were treated with growth hormone replacement]. [Current views on the etiopathogenesis of goiter in children]. [Guidelines concerning insulin dosage in children and adolescents with type 1 diabetes on continuous subcutaneous insulin infusion]. [Familial precocious puberty -- a variant of norm or pathology?]. [Growth failure in a boy with Klinefelter syndrome and IUGR].
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