影响妥布霉素气雾剂体外沉积的因素:超声雾化器与高频振动网状雾化器的比较。

Kenneth Manby Pedersen, Vagn Neerup Handlos, Lars Heslet, Henning Gjelstrup Kristensen
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引用次数: 29

摘要

该研究的目的是详细介绍机械通气期间的吸入建议,以优化分娩。在机械通气过程中,体外气溶胶从雾化器输送取决于呼吸机回路的尺寸、雾化器类型和呼吸机设置。对文献的回顾表明,一些呼吸机的设置对气溶胶释放量的影响比其他设置更大。体外模型显示,影响输送气溶胶的因素为呼吸机流量、气管插管直径和吸气时间(均p < 0.05)。研究中使用了两种不同类型的雾化器:超声波雾化器(SUN 345)和高频振动网状雾化器(Aeroneb Pro)。不同雾化器类型的给药量没有差异(p = 0.215)。为了优化产出量,应该使用最大可能的流量、气管插管和吸气时间。
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Factors influencing the in vitro deposition of tobramycin aerosol: a comparison of an ultrasonic nebulizer and a high-frequency vibrating mesh nebulizer.

The aim of the study was to elaborate recommendations for inhalation during mechanical ventilation that could optimize delivery. Delivery of aerosols in vitro from nebulizers during mechanical ventilation is dependent on the dimensions of the ventilator circuit, the nebulizer type, and the ventilator settings. A review of the literature shows that some ventilator settings have a larger influence on the amount of aerosol delivered than others. It has been shown in an in vitro model that the factors influencing delivered aerosol are the ventilator flow rate, the diameter of the endotracheal tube, and the time spent in inspiration (all p < 0.05). Two different nebulizer types were used in the study: an ultrasonic nebulizer (SUN 345) and a high-frequency vibrating mesh nebulizer (Aeroneb Pro). No difference in the amount delivered was seen with different nebulizer types (p = 0.215). For optimizing the amount delivered, the largest possible flow, endotracheal tube, and time spent in inspiration should be used.

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