等渗和高渗生理盐水滴在人上呼吸道模型中的沉积。

Zhe Zhang, Clement Kleinstreuer, Chong S Kim
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引用次数: 38

摘要

本文模拟了等渗和高渗盐水滴在层流-过渡-湍流吸气条件下从口腔到第四代气管-支气管树的蒸发和吸湿效应以及沉积。具体而言,分析了局部水蒸气输送、液滴蒸发速率和沉积分数。还讨论了吸入流速、空气热力学性质和氯化钠液滴浓度的影响。经过验证的计算机模拟结果表明,nacl溶质浓度的增加、进口相对湿度的增加或进口空气温度的降低都可能减少水的蒸发,增加盐水液滴表面的冷凝水,导致颗粒直径和密度的增加,导致液滴沉积量的增加。然而,低于10%的溶质浓度可能不会对人体上呼吸道中的液滴沉积产生非常明显的影响。
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Isotonic and hypertonic saline droplet deposition in a human upper airway model.

The evaporative and hygroscopic effects and deposition of isotonic and hypertonic saline droplets have been simulated from the mouth to the first four generations of the tracheobronchial tree under laminar-transitional-turbulent inspiratory flow conditions. Specifically, the local water vapor transport, droplet evaporation rate, and deposition fractions are analyzed. The effects of inhalation flow rates, thermodynamic air properties and NaCl-droplet concentrations of interest are discussed as well. The validated computer simulation results indicate that the increase of NaCl-solute concentration, increase of inlet relative humidity, or decrease of inlet air temperature may reduce water evaporation and increase water condensation at saline droplet surfaces, resulting in higher droplet depositions due to the increasing particle diameter and density. However, solute concentrations below 10% may not have a very pronounced effect on droplet deposition in the human upper airways.

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