Laura Diaz-Cueto, Adrian Cuica-Flores, Francisco Ziga-Cordero, Jose Antonio Ayala-Mendez, Gilberto Tena-Alavez, Pablo Dominguez-Lopez, Rocio Cuevas-Antonio, Fabian Arechavaleta-Velasco
{"title":"细菌性阴道病孕妇阴道基质金属蛋白酶水平。","authors":"Laura Diaz-Cueto, Adrian Cuica-Flores, Francisco Ziga-Cordero, Jose Antonio Ayala-Mendez, Gilberto Tena-Alavez, Pablo Dominguez-Lopez, Rocio Cuevas-Antonio, Fabian Arechavaleta-Velasco","doi":"10.1016/j.jsgi.2006.05.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare matrix metalloproteinase (MMP)-8 and MMP-9 levels in the vaginal secretions of pregnant women with or without asymptomatic bacterial vaginosis (BV).</p><p><strong>Methods: </strong>In this study, vaginal levels and molecular forms of MMP-8 and MMP-9 were studied in 36 pregnant women between 28 and 34 weeks of gestation with asymptomatic BV and 41 pregnant women, matched for gestational age, without BV.</p><p><strong>Results: </strong>Vaginal MMP-8 concentrations were significantly higher (P = .023) in BV-positive women. There was no significant difference in MMP-9 levels between healthy pregnant controls and BV-positive pregnant women. The presence of MMP-8 was confirmed by a 38-kd band on Western blots.</p><p><strong>Conclusions: </strong>Our findings show that BV is associated with increased levels of MMP-8 in vaginal fluid. Increased production of collagen-degrading enzymes such as MMP-8 is a possible cause of spontaneous preterm delivery in pregnant women with asymptomatic BV.</p>","PeriodicalId":17373,"journal":{"name":"Journal of the Society for Gynecologic Investigation","volume":"13 6","pages":"430-4"},"PeriodicalIF":0.0000,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jsgi.2006.05.008","citationCount":"25","resultStr":"{\"title\":\"Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis.\",\"authors\":\"Laura Diaz-Cueto, Adrian Cuica-Flores, Francisco Ziga-Cordero, Jose Antonio Ayala-Mendez, Gilberto Tena-Alavez, Pablo Dominguez-Lopez, Rocio Cuevas-Antonio, Fabian Arechavaleta-Velasco\",\"doi\":\"10.1016/j.jsgi.2006.05.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare matrix metalloproteinase (MMP)-8 and MMP-9 levels in the vaginal secretions of pregnant women with or without asymptomatic bacterial vaginosis (BV).</p><p><strong>Methods: </strong>In this study, vaginal levels and molecular forms of MMP-8 and MMP-9 were studied in 36 pregnant women between 28 and 34 weeks of gestation with asymptomatic BV and 41 pregnant women, matched for gestational age, without BV.</p><p><strong>Results: </strong>Vaginal MMP-8 concentrations were significantly higher (P = .023) in BV-positive women. There was no significant difference in MMP-9 levels between healthy pregnant controls and BV-positive pregnant women. The presence of MMP-8 was confirmed by a 38-kd band on Western blots.</p><p><strong>Conclusions: </strong>Our findings show that BV is associated with increased levels of MMP-8 in vaginal fluid. Increased production of collagen-degrading enzymes such as MMP-8 is a possible cause of spontaneous preterm delivery in pregnant women with asymptomatic BV.</p>\",\"PeriodicalId\":17373,\"journal\":{\"name\":\"Journal of the Society for Gynecologic Investigation\",\"volume\":\"13 6\",\"pages\":\"430-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jsgi.2006.05.008\",\"citationCount\":\"25\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Society for Gynecologic Investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jsgi.2006.05.008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2006/7/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Society for Gynecologic Investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jsgi.2006.05.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2006/7/26 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis.
Objective: To compare matrix metalloproteinase (MMP)-8 and MMP-9 levels in the vaginal secretions of pregnant women with or without asymptomatic bacterial vaginosis (BV).
Methods: In this study, vaginal levels and molecular forms of MMP-8 and MMP-9 were studied in 36 pregnant women between 28 and 34 weeks of gestation with asymptomatic BV and 41 pregnant women, matched for gestational age, without BV.
Results: Vaginal MMP-8 concentrations were significantly higher (P = .023) in BV-positive women. There was no significant difference in MMP-9 levels between healthy pregnant controls and BV-positive pregnant women. The presence of MMP-8 was confirmed by a 38-kd band on Western blots.
Conclusions: Our findings show that BV is associated with increased levels of MMP-8 in vaginal fluid. Increased production of collagen-degrading enzymes such as MMP-8 is a possible cause of spontaneous preterm delivery in pregnant women with asymptomatic BV.
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