使用旋转顶部气溶胶发生器生成单分散药理学气溶胶。

Martyn F Biddiscombe, Peter J Barnes, Omar S Usmani
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引用次数: 3

摘要

使用旋顶气溶胶发生器(STAG)可以产生精确控制粒径和窄分散的药理学气溶胶。STAG从原始药物化合物的溶液中产生单分散气溶胶的能力使其成为一种有价值的研究仪器。在本文中,该仪器的多功能性已通过雾化一系列市售雾化肺治疗制剂进一步证明。将氟替肽(丙酸氟替卡松)、普米克(布地奈德)、康必特(硫酸沙丁胺醇和溴化异丙托品)、布利肯尼(硫酸特布他林)、阿托文特(溴化异丙托品)和萨拉莫(硫酸沙丁胺醇)分别与乙醇混合并递送至STAG。在0.95 ~ 6.7 μ m的MMADs范围内产生单分散的药物气溶胶分布。为了从雾化器药物悬浮液中获得更大的颗粒尺寸,STAG形成了由较小的不溶性药物颗粒衍生的复合颗粒团块。这些复合团块在空气动力学上表现为单个颗粒,并通过空气动力学粒度仪和安德森级联撞击器进行了验证。扫描电镜图像显示了它们的物理结构。另一方面,使用雾化器药物溶液,生成与原始液滴直径成正比的球形颗粒。STAG产生的气溶胶可以让研究人员研究吸入药物沉积的科学原理和一系列治疗药物的肺部生理学。
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Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator.

Pharmacological aerosols of precisely controlled particle size and narrow dispersity can be generated using the spinning-top aerosol generator (STAG). The ability of the STAG to generate monodisperse aerosols from solutions of raw drug compounds makes it a valuable research instrument. In this paper, the versatility of this instrument has been further demonstrated by aerosolizing a range of commercially available nebulized pulmonary therapy preparations. Nebules of Flixotide (fluticasone propionate), Pulmicort (budesonide), Combivent (salbutamol sulphate and ipratropium bromide), Bricanyl (terbutaline sulphate), Atrovent(ipratropium bromide), and Salamol (salbutamol sulphate) were each mixed with ethanol and delivered to the STAG. Monodisperse drug aerosol distributions were generated with MMADs of 0.95-6.7 microm. To achieve larger particle sizes from the nebulizer drug suspensions, the STAG formed compound particle agglomerates derived from the smaller insoluble drug particles. These compound agglomerates behaved aerodynamically as a single particle, and this was verified using an aerodynamic particle sizer and an Andersen Cascade Impactor. Scanning electron microscope images demonstrated their physical structure. On the other hand using the nebulizer drug solutions, spherical particles proportional to the original droplet diameter were generated. The aerosols generated by the STAG can allow investigators to study the scientific principles of inhaled drug deposition and lung physiology for a range of therapeutic agents.

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