{"title":"心肌梗死后粒细胞集落刺激因子对干细胞活化的影响。","authors":"Hüseyin Ince, Christoph A Nienaber","doi":"10.1038/ncpcardio0732","DOIUrl":null,"url":null,"abstract":"<p><p>Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.</p>","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"4 Suppl 1 ","pages":"S119-22"},"PeriodicalIF":0.0000,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0732","citationCount":"13","resultStr":"{\"title\":\"Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction.\",\"authors\":\"Hüseyin Ince, Christoph A Nienaber\",\"doi\":\"10.1038/ncpcardio0732\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.</p>\",\"PeriodicalId\":51263,\"journal\":{\"name\":\"Nature Clinical Practice. Cardiovascular Medicine\",\"volume\":\"4 Suppl 1 \",\"pages\":\"S119-22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/ncpcardio0732\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Clinical Practice. Cardiovascular Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/ncpcardio0732\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Clinical Practice. Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/ncpcardio0732","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction.
Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.
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