面罩和体内气溶胶输送。

Simone Erzinger, Karen G Schueepp, Joanne Brooks-Wildhaber, Sunalene G Devadason, Johannes H Wildhaber
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引用次数: 90

摘要

体外实验表明,即使口罩中有很小的空气泄漏,也会大大降低给药效率。此外,研究表明,药物在面部的沉积确实会显著增加药物的整体损失,并有可能产生局部副作用。因此,本研究的目的是在体内验证这些发现。8名年龄在18-36个月的无症状复发性喘息儿童,通过带面罩的间隔器或带面罩的雾化器从加压计量吸入器吸入放射性标记的沙丁胺醇制剂。用伽马照相机评估放射性标记沙丁胺醇的药物沉积,并以总剂量的百分比表示。肺沉积占总剂量(分别为计量剂量和雾化器填充量)的百分比在使用非紧密贴合口罩吸入的儿童中为0.2%和0.3%。戴紧口罩的尖叫儿童的肺沉积率为0.6%和1.4%,呼吸正常的儿童的肺沉积率为4.8%至8.2%。总体掩膜沉积在0.8%至5.2%之间。整体面部沉积在2.6%至8.4%之间。这项初步研究的结果支持了在体外研究中发现的结果,在体外研究中,口罩泄漏大大减少了对患者的药物输送。
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Facemasks and aerosol delivery in vivo.

It has been shown in vitro that even a small air leak in the facemask can drastically reduce the efficiency of drug delivery. In addition, it has been shown that drug deposition on the face does significantly add to overall drug loss and has the potential of local side effects. The aim of this study is therefore to verify these findings in vivo. Eight asymptomatic recurrently wheezy children, aged 18-36 months, inhaled a radiolabeled salbutamol formulation either from a pressurized metered-dose inhaler through a spacer with attached facemask or from a nebulizer with attached facemask. Drug deposition of radiolabeled salbutamol was assessed with a gamma camera and expressed as a percentage of the total dose. Lung deposition expressed as a percentage of the total dose (metered dose and nebulizer fill, respectively) was 0.2% and 0.3% in children who inhaled with a non-tightly fitted facemask. Lung deposition was 0.6% and 1.4% in screaming children with a tightly fitted facemask and between 4.8% and 8.2% in patients breathing normally. Overall mask deposition was between 0.8% and 5.2%. Overall face deposition was between 2.6% and 8.4%. The results from this pilot study support the results found in in vitro studies, where a facemask leak greatly reduces drug delivery to the patient.

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