多QTL定位的统计方法。

Wei Zou, Zhao-Bang Zeng
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引用次数: 30

摘要

自1989年Lander和Botstein提出用于QTL定位数据分析的区间映射方法以来,近年来在QTL分析方面取得了巨大的进展,为QTL分析提供了新的、强大的统计方法。近年来的研究进展主要集中在多QTL组合的统计方法和问题上。在本文中,我们回顾了这一进展。我们重点讨论了通过最大似然和贝叶斯方法绘制多个QTL的统计方法,以及确定适当的分析阈值。
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Statistical Methods for Mapping Multiple QTL.

Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical methods for QTL analysis. Recent research progress has been focused on statistical methods and issues for mapping multiple QTL together. In this article, we review this progress. We focus the discussion on the statistical methods for mapping multiple QTL by maximum likelihood and Bayesian methods and also on determining appropriate thresholds for the analysis.

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