卒中后早期或晚期应用血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂预防主要心血管事件

Walter Van Mieghem
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引用次数: 1

摘要

中风是世界上第二大最常见的死亡原因,每年造成约500万人死亡。几项试验表明,阻断肾素-血管紧张素系统(RAS)可能对中风患者有益。最近报道的有效避免第二次中风的预防方案(PRoFESS)研究评估了血管紧张素受体阻滞剂(ARB)替米沙坦在中风后早期开始降低血压的效果。替米沙坦组共有80名患者(8.7%)和安慰剂组934名患者(9.2%)随后发生卒中,替米沙坦组的相对风险降低了5%。替米沙坦组有1367例(13.5%)患者发生了主要心血管事件,安慰剂组有1463例(14.4%)患者发生了主要心血管事件,相对风险降低了6%。PRoFESS研究的平均随访时间仅为2.5年,这对于评估治疗对动脉粥样硬化疾病的影响来说太短了。针对动脉粥样硬化过程的卒中预防对整个心血管系统都有影响。PRoFESS中主要心血管事件发生率的Kaplan-Meier曲线与心脏结局预防评估(HOPE)的Kaplan-Meier曲线有着惊人的相似性,欧洲关于稳定冠状动脉疾病中使用培哚普利减少心脏事件的试验(EUROPA)和心血管疾病ACE不耐受患者替米沙坦随机评估研究(TRANSCEND)试验的终点相似。极有可能的是,随着随访时间的延长,替米沙坦治疗和安慰剂治疗的患者之间的差异将变得显著。2008年,心血管疾病患者得到的治疗比10年前好得多。通过从用于预防这些高危患者的鸡尾酒中省略一类药物(他汀类药物,受体阻滞剂,抗血小板药物和血管紧张素转换酶抑制剂或ARBs),将失去完整治疗所获得的部分益处。乍一看,PRoFESS似乎是一个负面的试验,但如果与其他临床试验的现有数据一起考虑,它清楚地表明,在中风或其他动脉粥样硬化疾病患者中,拒绝使用抵消血管紧张素II作用的药物将是一个错误。
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Prevention of major cardiovascular events with an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker early or late after stroke.

Stroke is the second most frequent cause of death in the world and is responsible for about 5 million deaths each year. Several trials have raised the possibility that blocking the renin-angiotensin system (RAS) may be beneficial in patients with stroke. The recently reported Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study evaluated the effect of lowering blood pressure with the angiotensin receptor blocker (ARB), telmisartan, initiated early after stroke. A total of 80 patients (8.7%) in the telmisartan group and 934 patients (9.2%) in the placebo group had a subsequent stroke, a nonsignificant 5% relative risk reduction in the telmisartan group. Major cardiovascular events occurred in 1367 patients (13.5%) in the telmisartan group and in 1463 patients (14.4%) in the placebo group, a 6% nonsignificant relative risk reduction. The mean follow-up in the PRoFESS study was only 2.5 years, which was too short to assess the impact of treatment on atherosclerotic disease. Stroke prevention aimed at the atherosclerotic process has repercussions on the entire cardiovascular system. The Kaplan-Meier curve of the incidence of major cardiovascular events in PRoFESS has a striking similarity with the Kaplan-Meier curves of Heart Outcomes Prevention Evaluation (HOPE), EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) and Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) trials for a similar endpoint. It is highly probable that with a longer follow-up, the difference between telmisartan-treated and placebo-treated patients would become significant. In 2008, patients with cardiovascular disease are considerably better treated than 10 years ago. By omitting one class of drugs from the cocktail used for prevention in these high-risk patients (statins, beta-blockers, antiplatelet drugs and angiotensin-converting enzyme inhibitors or ARBs), part of the benefit obtained by the complete treatment will be lost. PRoFESS seems to be a negative trial at first sight, but if considered together with the available data from other clinical trials, it clearly shows that it would be a mistake to withhold drugs that counteract the effect of angiotensin II in patients with stroke or other atherosclerotic disease.

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