吲达帕胺与卡托普利对自发性高血压发生的影响比较。

Stanislava Vranková, Lydia Jendekova, Ludovit Paulis, Martina Sladkova, Fedor Simko, Olga Pechanova
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引用次数: 5

摘要

目的:观察噻嗪类利尿剂吲达帕胺和血管紧张素转换酶抑制剂卡托普利对自发性高血压、左心室肥厚(LVH)发展、一氧化氮生成和氧化状态的影响。方法:6周龄雄性自发性高血压大鼠(SHR)分别给予吲达帕胺(1mg /kg / d)或卡托普利(10mg /kg / d)或吲达帕胺加卡托普利联合治疗。治疗6周后,观察大鼠股动脉一氧化氮合酶(NOS)活性、NOS异构体蛋白表达、偶联二烯浓度及松弛反应。结果:吲达帕胺和卡托普利可部分预防年轻SHR患者血压升高。卡托普利与吲达帕胺相比降低LVH。吲达帕胺与卡托普利联合用药对高血压的预防效果是叠加性的。与吲达帕胺单药组相比,吲达帕胺与卡托普利联合治疗可提高主动脉NOS活性和内皮NOS蛋白表达,降低肾脏偶联二烯浓度。吲达帕胺和吲达帕胺联合卡托普利治疗增加了乙酰胆碱诱导的股动脉舒张。结论:卡托普利联合用药可降低LVH,吲达帕胺联合用药可提高NOS活性,降低氧化损伤。由此可见,吲达帕胺联合卡托普利治疗高血压的复杂保护作用可能是通过其对血压、肥厚和血管舒张的作用来发挥的。
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Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.

Objectives: The effects of indapamide, a thiazide-like diuretic, and captopril, an angiotensin-converting enzyme inhibitor, on spontaneous hypertension and the development of left ventricular hypertrophy (LVH), nitric oxide generation and oxidant status were investigated.

Methods: Six-week-old male spontaneously hypertensive rats (SHR) were treated with indapamide (1 mg/kg per day) or captopril (10 mg/kg per day) or a combination of indapamide plus captopril. After the 6-week treatment, nitric oxide synthase (NOS) activity, the expression of NOS isoform proteins, conjugated dienes concentration and relaxation responses of the femoral artery were analyzed.

Results: Indapamide and captopril partly prevented a blood pressure increase in young SHR. Captopril in contrast to indapamide reduced LVH. The effect of the combined indapamide and captopril treatment on the prevention of hypertension was additive. Combined indapamide and captopril treatment increased NOS activity and endothelial NOS protein expression in the aorta and decreased conjugated dienes concentration in the kidney compared with the indapamide monotherapy group. Indapamide and indapamide and captopril treatment increased acetylcholine-induced relaxation of the femoral artery.

Conclusion: Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation.

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Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects. Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. Hypertension and kidney alterations in rat offspring from low protein pregnancies.
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