来自茶叶的绿色纳米技术:茶叶中的植物化学物质作为生产生物相容性金纳米颗粒的基石。

Satish K Nune, Nripen Chanda, Ravi Shukla, Kavita Katti, Rajesh R Kulkarni, Subramanian Thilakavathi, Swapna Mekapothula, Raghuraman Kannan, Kattesh V Katti
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引用次数: 351

摘要

茶叶中的植物化学物质被广泛用作膳食补充剂和天然药物,用于治疗包括人类癌症在内的各种疾病。本文研究了茶叶中植物化学物质将金盐还原为相应的金纳米颗粒的能力。茶叶中存在的植物化学物质具有双重作用,既是有效的还原剂,可以减少金的含量,也是稳定剂,可以在一步中在金纳米颗粒上提供坚固的涂层。茶生成的金纳米颗粒(T-AuNPs)在不同的缓冲液中表现出显著的体外稳定性,包括生理盐水、组氨酸、HSA和半胱氨酸溶液。具有植物化学包被的T-AuNPs对前列腺(PC-3)和乳腺癌(MCF-7)癌细胞显示出显著的亲和力。本文给出了T-AuNPs通过内吞作用进入PC-3和MCF-7细胞的细胞内化结果。T-AuNPs的产生遵循绿色化学的所有原则,并且通过MTT检测被发现是无毒的。在这种真正的生物绿色纳米技术过程中,除了金盐外,没有使用任何“人造”化学物质,因此为它们在分子成像和治疗中的应用提供了极好的机会。
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Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles.

Phytochemicals occluded in tea have been extensively used as dietary supplements and as natural pharmaceuticals in the treatment of various diseases including human cancer. Results on the reduction capabilities of phytochemicals present in tea to reduce gold salts to the corresponding gold nanoparticles are presented in this paper. The phytochemicals present in tea serve the dual roles as effective reducing agents to reduce gold and also as stabilizers to provide robust coating on the gold nanoparticles in a single step. The Tea-generated gold nanoparticles (T-AuNPs), have demonstrated remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. T-AuNPs with phytochemical coatings have shown significant affinity toward prostate (PC-3) and breast (MCF-7) cancer cells. Results on the cellular internalization of T-AuNPs through endocytosis into the PC-3 and MCF-7 cells are presented. The generation of T-AuNPs follows all principles of green chemistry and have been found to be non toxic as assessed through MTT assays. No 'man made' chemicals, other than gold salts, are used in this true biogenic green nanotechnological process thus paving excellent opportunities for their applications in molecular imaging and therapy.

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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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