吲哚菁绿基丝素治疗纳米探针用于宫颈疾病体内nir /II荧光成像的临床研究

IF 4.7 4区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 DOI:10.1016/j.nano.2022.102615
Rong Ma PhD , Xiaohui Tang MS , Mei Wang PhD , Zhong Du MS , Shuang Chen MS , Youqiang Heng MS , Lijun Zhu MS , Nuernisha Alifu PhD , Xueliang Zhang PhD , Cailing Ma PhD
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引用次数: 3

摘要

淋巴结病、输卵管阻塞等宫颈疾病威胁着女性的健康。然而,传统的诊断方法仍然存在不足。NIR-II荧光成像具有低散射、可忽略自身荧光和高空间分辨率的优点,可能是一种理想的选择。为了获得高质量的NIR-II荧光成像,选择合适的纳米探针成为重要问题。ICG作为一种小分子光热剂,由于其自身的缺陷,限制了其广泛应用。本文合成了天然丝素(SF)并包封ICG分子形成SF@ICG纳米粒子(NPs)。经过详细分析,SF@ICG NPs在808 nm激光照射下表现出优异的稳定性和较长的循环时间,具有较强的NIR-II荧光发射,良好的光稳定性、生物相容性和光热性能。此外,SF@ICG NPs用于淋巴结/淋巴管造影和输卵管血管造影的NIR-II荧光成像。该方法具有分辨率高、灵敏度高的特点。
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Clinical indocyanine green-based silk fibroin theranostic nanoprobes for in vivo NIR-I/II fluorescence imaging of cervical diseases

Cervical diseases such as lymph node disease and tubal obstruction have threatened women's health. However, the traditional diagnostic methods still have shortcomings. NIR-II fluorescence imaging with advantages of low scattering, negligible autofluorescence, and high spatial resolution could be an ideal option. To obtain high quality NIR-II fluorescence imaging, selecting appropriate nanoprobes becomes the important issue. As a small molecular photothermal agent, extensive applications of ICG are rather limited because of its drawbacks. Herein, natural silk fibroin (SF) was synthesized and encapsulated ICG molecules to form SF@ICG nanoparticles (NPs). After detailed analysis, SF@ICG NPs showed excellent stability and long circulation time, as well as strong NIR-II fluorescence emission, well photo-stability, biocompatibility and well photothermal property under 808 nm laser irradiation. Furthermore, SF@ICG NPs were utilized for NIR-II fluorescence imaging of lymph node/lymphangiography and angiography of fallopian tubes. The process of fallopian tubes could be detected with high resolution and high sensitivity.

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来源期刊
CiteScore
8.10
自引率
3.60%
发文量
104
审稿时长
4.6 months
期刊介绍: Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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