Paula Muresan PhD , Stephen Woodhams PhD , Fiona Smith MPharm , Vincenzo Taresco PhD , Jaymin Shah PhD , Mei Wong PhD , Victoria Chapman PhD , Stuart Smith MD, PhD , Gareth Hathway PhD , Ruman Rahman PhD , Pavel Gershkovich PhD , Maria Marlow PhD
{"title":"评估大麻二酚纳米颗粒和纳米乳在鞘内给药治疗疼痛后中枢神经系统的生物分布","authors":"Paula Muresan PhD , Stephen Woodhams PhD , Fiona Smith MPharm , Vincenzo Taresco PhD , Jaymin Shah PhD , Mei Wong PhD , Victoria Chapman PhD , Stuart Smith MD, PhD , Gareth Hathway PhD , Ruman Rahman PhD , Pavel Gershkovich PhD , Maria Marlow PhD","doi":"10.1016/j.nano.2023.102664","DOIUrl":null,"url":null,"abstract":"<div><p>We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached C<sub>max</sub> in the brain at 210 ng/g within 120 min (T<sub>max</sub>), whereas the CBD PCNPs had a C<sub>max</sub> of 94 ng/g at 30 min (T<sub>max</sub>), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC<sub>0</sub><sub>–</sub><sub>4</sub> <sub>h</sub> of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.</p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"49 ","pages":"Article 102664"},"PeriodicalIF":4.7000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain\",\"authors\":\"Paula Muresan PhD , Stephen Woodhams PhD , Fiona Smith MPharm , Vincenzo Taresco PhD , Jaymin Shah PhD , Mei Wong PhD , Victoria Chapman PhD , Stuart Smith MD, PhD , Gareth Hathway PhD , Ruman Rahman PhD , Pavel Gershkovich PhD , Maria Marlow PhD\",\"doi\":\"10.1016/j.nano.2023.102664\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached C<sub>max</sub> in the brain at 210 ng/g within 120 min (T<sub>max</sub>), whereas the CBD PCNPs had a C<sub>max</sub> of 94 ng/g at 30 min (T<sub>max</sub>), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC<sub>0</sub><sub>–</sub><sub>4</sub> <sub>h</sub> of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.</p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":\"49 \",\"pages\":\"Article 102664\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963423000151\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963423000151","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain
We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached Cmax in the brain at 210 ng/g within 120 min (Tmax), whereas the CBD PCNPs had a Cmax of 94 ng/g at 30 min (Tmax), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC0–4h of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.
期刊介绍：
Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
